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- **BRUKINSA leadership**: $1.1B Q3 revenue, 51% growth, solidifying global BTK dominance.
- **Sonro breakthrough**: 74% 6-year PFS vs. 62% for competitors, FDA Breakthrough Designation in MCL.
- **CDAC advantage**: 86% ORR, 79% 12-month PFS vs. 62% for competitors in CLL Phase III.
- **ZS combo dominance**: 92% uMRD at 1 year vs. 32% for AV, 4x faster MRD achievement.

**【CEO Summary Section】**
- BRUKINSA achieved $1.1 billion in Q3 revenue, up 41% YoY, solidifying its position as the global BTK leader with 51% Q3 growth.
- Sonro, the BCL-2 inhibitor, received FDA Breakthrough Therapy Designation in relapsed/refractory mantle cell lymphoma, with 74% 6-year PFS in CLL vs. 62% for competitors.
- 2025 guidance updated to $5.1-5.3 billion revenue, driven by BRUKINSA and sonro expansion.

**【CFO Financial Commentary】**
- Q3 2025 GAAP net income: $125 million; non-GAAP net income: $304 million, with $354 million free cash flow.
- BRUKINSA gross margin improved to 86%, supported by favorable product mix and cost efficiencies.
- 2025 R&D expenses: $1.1 billion, reflecting investment in late-stage assets like CDAC and sonro.

**【R&D & Pipeline Update】**
- CDAC (BTK degrader) Phase III vs. pirtobrutinib in relapsed CLL; 86% ORR, 79% 12-month PFS vs. 62% for competitors.
- Sonro Phase III ZS combo vs. AV in CLL: 92% uMRD at 1 year vs. 32% for AV, with 4-month MRD achievement vs. 16 months for AV.
- 10 new molecular entities advancing, including PRMT5 and B7-H4 ADCs with early POC in solid tumors.

**【Q&A Highlights】**
- BRUKINSA Europe growth: 70% Q3, but slower adoption in Germany due to guideline delays.
- CDAC Phase III in CLL expected H1 2026; targeting 12-month PFS readout for accelerated approval.
- Sonro combo ZS vs. AV in CLL: 74% 6-year PFS vs. 62% for AV, with no progression in 320mg cohort.
- GPC3 x 4-1BB ADC shows 83% ORR in PDAC, positioning for frontline trials in 2026.

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