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- **Revenue Surge**: Q3 revenue up 17% YoY to $157M, driven by TRYNGOLZA ($32M Q3 sales) and DAWNZERA launches. 2025 guidance raised to $875-900M.
- **Pipeline Milestones**: Olezarsen shows 85% AP reduction in sHTG; zilganersen stabilizes Alexander disease gait speed. Both targeting 2026 launches.
- **Strategic Growth**: >$1B peak sales expected for olezarsen; DAWNZERA >$500M. 4 partnered launches by 2027, with $2.1B+ cash for execution.

**【CEO Summary Section】**
- **Strong Launch Momentum**: TRYNGOLZA achieved $32M in Q3 sales, up 70% QoQ, with 70% prescribers from cardiologists and endocrinologists. DAWNZERA secured first prescriptions within 10 days of approval, with early adoption from HAE patients.
- **Pipeline Breakthroughs**: Olezarsen reduced triglycerides by 72% in sHTG and acute pancreatitis events by 85%, while zilganersen showed disease-modifying effects in Alexander disease. Both programs target 2026 launches.
- **Partnership Growth**: 4 partnered pipeline launches expected by 2027, targeting rare and prevalent diseases, with Sobi initiating European TRYNGOLZA rollout.

**【CFO Financial Commentary】**
- **Revenue Growth**: Q3 revenue $157M (+17% YoY), 9M total $740M (+55% YoY). TRYNGOLZA sales guidance raised to $85-95M for 2025. Non-GAAP operating loss $275-300M, with $2.1B+ cash balance.
- **Cost Management**: Year-to-date non-GAAP expenses up 9%, driven by U.S. launch investments. R&D expenses down YoY, with 23% of R&D funding late-stage programs.

**【Q&A Highlights】**
- **Olezarsen Launch Strategy**: Targeting 20,000 HCPs in sHTG, with 360,000 high-risk patients. Expected peak sales >$1B, driven by 85% AP reduction and triglyceride lowering. Pricing decisions pending AHA data (Nov 8).
- **DAWNZERA Market Potential**: >$500M peak sales in HAE, with 7,000 U.S. patients, 75% on prophylaxis. Early adoption from switch and treatment-naive patients.
- **Pipeline Investment**: $2.1B+ cash balance supports 2026 launches of olezarsen and zilganersen, with disciplined capital allocation prioritizing internal growth.

Ionis Pharmaceuticals, Inc. (IONS) Q3 2025 Earnings Call Transcript

- **Revenue Beat**: Q2 revenue $452M (+100% YoY), 2025 guidance raised to $850M. Tryngolza sales $19M (Q2) vs. $6M (Q1).
- **Pipeline Breakthroughs**: Donidalorsen HAE launch on track (August 21), Olezarsen sHTG Phase III data in Q3. Zilganersen Alexander's disease readout Q4.
- **Commercial Excellence**: 90% patient OOP coverage, 3,000+ HCP engagements, 60% commercial payer mix for Tryngolza.
- **Financial Strength**: $2B cash balance, 70% YoY revenue growth, operating loss narrowing to $300-325M.

**【CEO Summary Section】**
- **Strong Q2 Performance**: Revenue of $452 million (2x YoY), driven by Tryngolza's $19 million net sales (3x Q1). Updated 2025 guidance: $850 million revenue, up $100 million from prior.
- **Pipeline Momentum**: 2025 launches include Donidalorsen (HAE) and Olezarsen (sHTG). Phase III data expected for Zilganersen (Alexander's disease) and Olezarsen (sHTG) in Q3.
- **Commercial Success**: Tryngolza's 90% patient OOP coverage, 3,000+ HCP engagements, and 60% commercial payer mix highlight execution strength.

**【CFO Financial Commentary】**
- **Q2 Financials**: Non-GAAP net income $154 million; 70% YoY first-half revenue growth to $584 million. Operating expenses +8% YoY, with 2/3 of R&D funding late-stage programs.
- **Guidance Update**: 2025 revenue $850M (vs. $750M prior), operating loss $300-325M, cash balance $2B. Tryngolza 2025 sales $75-80M, Donidalorsen modest 2025 contribution.

**【Q&A Highlights】**
- **Tryngolza Growth**: Sequential Q3/Q4 growth driven by FCS patient identification; 3,000+ potential U.S. patients. Q2 sales $19M, Q1 $6M.
- **sHTG Data Expectations**: Olezarsen targeting 50-60% triglyceride reduction vs. SoC. CORE/CORE2 AP events exceed FCS BALANCE (13 events), supporting trend analysis.
- **Donidalorsen Launch**: FDA PDUFA August 21; 20,000+ U.S. HAE patients, 20% annual therapy switch rate. Switch study shows 62% attack reduction, 84% patient preference.
- **Pricing Strategy**: sHTG pricing TBD post-data; focus on sHTG as 1M+ U.S. patients with high-risk triglycerides.

Ionis Pharmaceuticals, Inc. (IONS) Q2 2025 Earnings Call Transcript

- **Revenue Beat**: Q1 $132M (+10% YoY), driven by $6M+ TRYNGOLZA sales and licensing deals. 2025 guidance raised to $725-750M.
- **Pipeline Momentum**: 4 late-stage programs (sHTG, Alexander's, sapablursen, Angelman) with multibillion-dollar potential.
- **Commercial Success**: TRYNGOLZA 90%+ patient zero copay, donidalorsen 84% patient preference in SWITCH study.
- **Financial Strength**: $1.9B cash, operating loss reduced to <$375M, +25% cost efficiency.

**【CEO Opening Remarks】**
- **Strategic Focus**: Emphasized execution on strategic priorities amid FDA and tariff policy uncertainties. Highlighted successful licensing deals driving 2025 financial guidance upgrade.
- **Product Launch Momentum**: TRYNGOLZA (FCS) exceeded Q1 expectations with $6M+ sales, targeting 3,000+ U.S. patients. Donidalorsen (HAE) on track for Q3 launch with potential $500M+ peak sales.
- **Pipeline Expansion**: 4 late-stage programs (olezarsen sHTG, zilganersen Alexander's disease, sapablursen, ION582) poised for 2025-2026 data reads, representing multibillion-dollar revenue potential.

**【CFO Financial Update】**
- **Q1 2025 Results**: Revenue $132M (+10% YoY), with $6M+ product sales from TRYNGOLZA. SPINRAZA royalties $48M (+25% YoY), WAINUA royalties $9M.
- **Guidance Upgrade**: 2025 revenue raised to $725-750M (+20% YoY), driven by sapablursen licensing ($280M upfront) and growing commercial portfolio. Operating loss reduced to <$375M, cash position $1.9B.
- **Cost Efficiency**: Non-GAAP expenses +<5% YoY, disciplined R&D allocation to late-stage programs.

**【Commercial Highlights】**
- **TRYNGOLZA Execution**: 90%+ patient zero copay, 50% cardiologist prescribers, favorable payer access. Focused on new patient identification and HCP education.
- **Olezarsen Progress**: Phase III data expected Q3, targeting 1M+ sHTG patients. ESSENCE safety study data Q2, sNDA submission Q4 if positive.
- **Donidalorsen Prep**: Field team 90%+ hired, HAE market 20,000+ U.S. patients with 20% annual therapy switching rate. SWITCH study shows 84% patient preference over prior treatments.

**【Q&A Key Takeaways】**
- **FDA & Tariff Impact**: No delays in donidalorsen PDUFA (August 21) or clinical trials. Manufacturing supply chain diversified (U.S., Europe, South Korea), no material tariff impact to date.
- **sHTG AP Risk Reduction**: CORE/CORE2 trials not powered for AP, but 22%/13% baseline AP history in cohorts. Combining datasets for secondary analysis, targeting triglyceride reduction as primary endpoint.
- **WAINUA Growth**: Medicare Part D redesign expected to increase patient access and adherence. AstraZeneca reports strong U.S. demand, EU approval expansion.
- **Angelman Syndrome**: Phase III start Q2, enrollment on track for 2026 completion, leveraging FDA-aligned trial design.


Ionis Pharmaceuticals (IONS)-30 Apr 25-2025 Q1 Earnings call transcript

- **Breakthrough Launch**: TRYNGOLZA achieved first patient treatment in 2 weeks post-FDA approval, with early momentum in FCS and sHTG markets.
- **$5B+ Revenue Vision**: Ionis targets $3B from owned medicines (olezarsen, ION582) and $2B in royalties, driven by 7 Phase III readouts by 2026.
- **2025 Financial Confidence**: >$600M revenue, <4.95 billion operating loss, and $1.7B cash, supported by WAINUA growth (84% Q4 sales growth) and new launches.
- **Clinical Excellence**: sHTG Phase III powered for triglyceride reduction, with potential AP event reduction; Angelman Phase III enrollment on track with 2 dose levels.

**【CEO Summary Section】**
- Launched TRYNGOLZA for FCS in Q4 2024, achieving first patient treatment within 2 weeks of FDA approval.
- Projected 3 additional independent launches over the next 3 years: donidalorsen (HAE, Q3 2025), sHTG indication for olezarsen (2025), and zilganersen (Alexander disease, 2026).
- 4 partnered launches expected over the next 3 years, including pelacarsen (Lp(a) CVD), eplontersen (ATTR-CM), bepirovirsen (HBV), and sefaxersen (IgAN).
- Total peak revenue potential exceeds $5 billion, driven by $3 billion from Ionis-owned medicines and $2 billion in royalties from partnered programs.

**【CFO Financial Commentary】**
- 2024 non-GAAP operating loss: $345 million (vs. $495 million guidance), with revenue of $705 million (+$130M over guidance).
- Key revenue sources: SPINRAZA royalties ($216M), WAINUA product sales ($85M), and early TRYNGOLZA contributions.
- 2025 guidance: >$600M revenue, <4.95 billion in non-GAAP operating loss, and $1.7 billion cash by year-end.
- Revenue growth driven by commercial expansion (TRYNGOLZA, donidalorsen) and partnered programs (WAINUA, SPINRAZA).

**【Q&A Highlights】**
- **sHTG Launch Dynamics**: Phase III data expected H2 2025, with sNDA submission planned post-CORE/CORE2 results. Focus on 500+ mg/dL triglyceride population with high unmet need.
- **WAINUA Growth**: Q4 2024 sales up 84% QoQ, 40% new-to-brand share, and >80% patients paying $0 out-of-pocket.
- **Partnership Strategy**: Securing OUS partners for FCS/sHTG, while retaining global rights for alpha-synuclein (MSA) and LRRK2 (PD) programs.
- **Angelman Enrollment**: Phase III initiation H1 2025, targeting 300+ patients with 2 dose levels powered against placebo.

**【Operational Milestones】**
- HAE launch prep: hired donidalorsen VP of Sales, with field teams to be finalized pre-August 2025 PDUFA date.
- sHTG commercial readiness: scaling Ionis Every Step program for broader patient engagement.
- Pipeline advancement: 7 Phase III readouts by end-2026, including zilganersen (Alexander disease) and ION582 (Angelman syndrome).

Ionis Pharmaceuticals (IONS)-19 Feb 25-2024 Q4 Earnings call transcript

Ionis Pharmaceuticals (IONS)-6 Nov 24-2024 Q3 Earnings call transcript

Ionis Pharmaceuticals (IONS)-1 Aug 24-2024 Q2 Earnings call transcript

Ionis Pharmaceuticals (IONS)-7 May 24-2024 Q1 Earnings call transcript

Ionis Pharmaceuticals, Inc. (IONS) Q4 2023 Earnings Call Transcript

Ionis Pharmaceuticals (IONS)-2 Nov 23-2023 Q3 Earnings call transcript

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Ionis Pharmaceuticals (IONS)-11 Nov 17-2017 Q3 Earnings call transcript

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