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What is the market's earnings forecast for Syndax next quarter?

What guidance did Syndax's management provide for the next earnings period?

What factors drove the changes in Syndax's revenue and profit?

What is Syndax's latest dividend and current dividend yield?

What is Syndax's gross profit margin?

Did Syndax beat or miss consensus estimates last quarter?

- **Revenue Surpassing Expectations**: 2025 total revenue of $172.4 million, with Revuforj and Niktimvo driving 72% and 24% of sales, respectively.
- **Market Leadership**: 38% QoQ growth in Revuforj and 22% in Niktimvo, with Revuforj capturing >30% of NPM1 new patient starts in Q4.
- **Pipeline Catalysts**: Phase II IPF data expected Q4 2026 and frontline Revuforj trials poised to unlock $5+ billion market opportunity.
- **Financial Strength**: $394 million cash balance supports 2026 expenses without dilution, with Niktimvo margin contribution set to expand.

**【CEO Summary Section】**
- **Revenue Growth**: Total revenue for 2025 was $172.4 million, driven by $124.8 million in Revuforj net revenue and $42.4 million in Niktimvo collaboration revenue. Fourth-quarter Revuforj net revenue grew 38% YoY, while Niktimvo net revenue increased 22% QoQ.
- **Commercial Momentum**: Revuforj achieved 38% QoQ growth in the fourth quarter, with 35% of new patient starts in NPM1 mutated AML. Niktimvo reached $151.6 million in net revenue in its first 11 months, surpassing industry benchmarks.
- **Pipeline Progress**: Frontline trials for Revuforj (EVOLVE-2, REVEAL) and axatilimab's Phase II IPF trial (MAXPIRe) are advancing, with potential for $5 billion+ market expansion.

**【CFO Financial Commentary】**
- **Financial Health**: Syndax ended 2025 with $394 million in cash, enabling stable expenses of $400 million in 2026. Niktimvo's margin contribution is expected to grow as sales ramp while costs remain fixed.
- **Revenue Breakdown**: Revuforj accounted for 72% of total revenue, Niktimvo 24%, and milestones 4%. Fourth-quarter Revuforj net revenue was $44.2 million, up 38% from Q3.

**【Q&A Highlights】**
- **NPM1 Market Share**: Executives expect NPM1 patients to represent >50% of new starts by 2026, driven by Revuforj's best-in-class profile and 97% formulary coverage.
- **IPF Trial Outlook**: MAXPIRe's primary endpoint (FVC decline) is expected to show ≥40 mL improvement, aligning with historical benchmarks for approval.
- **Competitive Position**: Syndax maintains >80% prescriber activation for Revuforj, outpacing competitors with faster formulary access and superior efficacy data.

Syndax Pharmaceuticals, Inc. (SNDX) Q4 2025 Earnings Call Transcript

- **Revenue Surge**: Q3 revenue up 21% to $45.9 million, driven by Revyforge ($32M, +12%) and Nictimvo ($45.8M, +27%).
- **Market Expansion**: FDA approval triples Revyforge’s addressable population; 50% of usage in second-line KMT2A.
- **Profitability Path**: $456M cash, stable expenses, confident in reaching profitability.
- **Clinical Excellence**: 79% response rate in real-world use, 100% MRD negativity in frontline trials.
- **Growth Drivers**: Post-transplant maintenance to offset transplant pauses; NPM1 launch on track for Q4 acceleration.

**【CEO Opening Remarks】**
- Q3 2025 total revenue of $45.9 million, up 21% quarter-over-quarter, driven by Revyforge and Nictimvo launches. Revyforge net revenue $32 million (12% QoQ growth), Nictimvo collaboration revenue $13.9 million. FDA approval for Revyforge in NPM1 AML triples addressable population; 50% of Revyforge usage in second-line KMT2A. $456 million cash, confident in reaching profitability with current funds.

**【Commercial Progress】**
- **Revyforge**: 25% QoQ growth in prescriptions/new starts; 35%-40% patients restarting post-transplant. 90% of KMT2A usage in second/third-line; 50% of patients proceed to transplant. NPM1 launch: 2,200+ prescriptions in first week, 97% formulary coverage.
- **Nictimvo**: $45.8 million net sales (27% QoQ), 80% of Q1 patients remain on therapy.

**【ASH Presentations】**
- **Revyforge**: 79% overall response rate in real-world KMT2A/NPM1; 86% MRD negativity in KMT2A. Frontline trial: 88% CR in NPM1/KMT2A, 100% MRD negative. Post-transplant maintenance: 100% 1-year EFS in pediatric review.
- **Nictimvo**: Positive safety and efficacy in chronic GVHD combination trials.

**【Financial Results】**
- **Revenue Breakdown**: Revyforge: $32 million (12% QoQ), 25% gross-to-net adjustments. Nictimvo: $13.9 million (27% QoQ), 25%-30% margin contribution.
- **Cash Position**: $456 million, sufficient for commercial and clinical execution.

**【Q&A Highlights】**
- **Lines of Therapy**: Revyforge used earlier in KMT2A (70% second-line), NPM1 expected to follow.
- **Duration of Therapy**: 4-6 months in 2025, 6-12+ in 2026 as post-transplant maintenance grows.
- **Payer Access**: 97% formulary coverage for KMT2A, rapid build for NPM1.
- **Competitive Edge**: Best-in-class efficacy, 1-year first-mover advantage in NPM1.

Syndax Pharmaceuticals, Inc. (SNDX) Q3 2025 Earnings Call Transcript

- **Revenue Surge**: Q2 2025 net sales of $64.8 million, driven by 43% QoQ growth in Revuforj and $36.2 million in Niktimvo revenue.
- **Market Dominance**: Revuforj treats 25% of annual KMT2A patients in 7 months, Niktimvo achieves 80% retention in GVHD.
- **Strategic Wins**: sNDA for NPM1 AML with October 2025 PDUFA date; Phase II IPF trial on track for 2026 data.
- **Profitability Path**: Niktimvo profitable in Q2, Revuforj on track for relapsed/refractory profitability with 4-6 month treatment durations.
- **Pipeline Momentum**: Frontline trials enrolling; Niktimvo advancing into GVHD earlier lines and IPF.

**【CEO Summary Section】**
- **Revenue Growth**: Revuforj and Niktimvo combined net sales reached $64.8 million in Q2, with Revuforj growing 43% QoQ to $28.6 million and Niktimvo reporting $36.2 million in net revenue.
- **Market Leadership**: Revuforj is the only FDA-approved therapy for relapsed/refractory KMT2A acute leukemia, treating over 500 patients (90% on-label) in 7 months. Niktimvo achieved 80% patient retention in chronic GVHD.
- **Strategic Expansion**: sNDA for Revuforj in mutant NPM1 AML with PDUFA date October 25, 2025. Frontline trials (EVOLVE-2 and REVEAL) for Revuforj in combination therapies are enrolling patients.
- **Pipeline Momentum**: Niktimvo advancing into IPF with Phase II trial enrollment expected to complete in Q4 2025.

**【CFO Financial Commentary】**
- **Profitability Path**: Niktimvo contributed $9.4 million in collaboration revenue (20-30% margin), with Revuforj on track for relapsed/refractory profitability. Full-year operating expenses guided at $370-390 million, stable through 2027.
- **Balance Sheet Strength**: $518 million in cash as of Q2, supporting launches and clinical development without dilution.
- **Revenue Drivers**: Revuforj expected to benefit from longer treatment durations (4-6 months in Q2, expanding to 6-12+ months) and post-transplant maintenance. Niktimvo's chronic nature supports multi-year patient adherence.

**【Q&A Highlights】**
- **Revuforj Transplant Rate**: 1/3 of KMT2A patients proceeded to transplant in Q2, higher than 1/4 in clinical trials. Physicians expect 70-90% of eligible patients to restart post-transplant.
- **FDA Confidence**: sNDA for NPM1 AML on priority review with PDUFA date October 25, 2025. Regulatory team reports positive engagement and no major issues.
- **Niktimvo Growth**: 70% of GVHD centers using Niktimvo, with 1,000+ patients treated. Phase II IPF trial targeting 135 patients, with data expected H2 2026.
- **Competitive Position**: Revuforj's best-in-class efficacy and first-to-market advantage in menin inhibition; Niktimvo's novel mechanism in GVHD.

Syndax Pharmaceuticals, Inc. (SNDX) Q2 2025 Earnings Call Transcript

- **Revenue Growth**: Q1 2025 net sales of $33.6 million for Revuforj and Niktimvo, exceeding expectations with strong commercial execution.
- **Pipeline Momentum**: Initiated EVOLV-2 trial and submitted sNDA for Revuforj, positioning for accelerated approvals.
- **Financial Resilience**: $602.1 million cash balance supports long-term growth and clinical expansion.
- **Market Leadership**: First-to-market advantage in menin inhibition with Revuforj, driving early adoption in relapsed AML.

**【CEO Summary Section】**
- **Revenue Performance**: Q1 2025 net revenue of $20 million for Revuforj and $13.6 million for Niktimvo, driven by strong commercial execution and unmet patient need.
- **Pipeline Advancements**: Initiated EVOLV-2 trial for frontline revumenib in unfit AML patients and submitted sNDA for Revuforj in mutant mNPM1 AML under FDA's RTOR program.
- **Financial Strength**: $602.1 million in cash, well-positioned for near-term profitability and future growth.

**【CFO Financial Commentary】**
- **Revenue Breakdown**: 50% share of Niktimvo net commercial profit resulted in $200,000 loss in Q1, with expectations for rapid conversion to positive contribution.
- **Cost Management**: Channel inventory maintained at 2-3 weeks, minimizing supply chain risk.
- **Liquidity**: Strong cash position supports ongoing operations and clinical development.

**【Commercial Progress】**
- **Revuforj Adoption**: 44% of high-priority accounts ordered by end of Q1, with 80% of prescribers reordering for additional patients.
- **Niktimvo Momentum**: Over 1,250 infusions administered in first two months, with 95% of top GVHD centers activated.

**【Pipeline Updates】**
- **EVOLV-2 Trial**: Amended to include complete remission and overall survival as dual primary endpoints for potential accelerated approval.
- **sNDA Submission**: Leveraging RTOR program for priority review, with potential for first-to-market approval in mutant mNPM1 AML.

**【Q&A Highlights】**
- **Revuforj Repeat Prescribers**: 80% of early prescribers reordered, with anecdotal evidence of post-transplant use.
- **Niktimvo Market Access**: 72% formulary coverage achieved, with J-code enabling efficient reimbursement.
- **EVOLV-2 Design**: Trial powered for NPM1 population, with dual endpoints to support accelerated approval pathways.

Syndax Pharmaceuticals (SNDX)-5 May 25-2025 Q1 Earnings call transcript

- **First-quarter revenue milestone**: $7.7 million in Revuforj sales highlight strong early demand and execution.
- **Strategic financing**: $350 million from Royalty Pharma underscores Niktimvo's multibillion-dollar potential.
- **Pipeline expansion**: sNDA for mutant NPM1 AML expected in Q2 2025, with frontline trials advancing.
- **Commercial momentum**: 33% of high-priority accounts ordering Revuforj, with Niktimvo targeting a $1.5-$2 billion market.
- **Financial strength**: $692 million in cash and no gross-to-net pressures support long-term growth.

**【CEO Summary Section】**
- Syndax reported $7.7 million in net revenue for Revuforj in Q4 2024, marking the first quarter with product revenue.
- The company secured a $350 million upfront payment from Royalty Pharma for a capped royalty on Niktimvo sales, reinforcing its financial position.
- Revuforj demonstrated strong early demand, with 33% of high-priority accounts ordering the drug, and plans to file an sNDA for mutant NPM1 AML by Q2 2025.
- Niktimvo launched in January 2025 for chronic GVHD, targeting a $1.5-$2 billion U.S. market opportunity.

**【CCO Commercial Progress】**
- Revuforj achieved $7.7 million in 5 weeks, with 1/3 of sales attributed to inventory and the remainder to patient demand.
- 33% of Tier 1 and Tier 2 accounts (representing 2/3 of patient opportunity) have ordered Revuforj, and most accounts have written multiple prescriptions.
- Niktimvo is being evaluated in combination trials with Jakafi and steroids, with IPF data expected in 2026.

**【R&D Updates】**
- Revuforj showed a 48% overall response rate in relapsed/refractory mutant NPM1 AML, with 23% achieving CR/CRh, supporting an sNDA submission in Q2 2025.
- A Phase II trial of Revuforj with venetoclax/azacitidine in frontline AML achieved a 100% overall response rate, with 95% MRD negativity.
- Frontline trials in both fit and unfit populations are planned for 2025, leveraging MRD as a potential endpoint.

**【CFO Financial Highlights】**
- Q4 2024 operating expenses were $104.0 million, with $65.5 million in R&D and $37.7 million in SG&A.
- Cash, equivalents, and investments totaled $692.4 million as of December 31, 2024.
- Niktimvo revenue will be split 50/50 with Incyte, with collaborative arrangement revenue or loss recognized based on commercial profit.

**【Q&A Key Takeaways】**
- Inventory levels are expected to remain at 2-3 weeks, with no significant gross-to-net adjustments.
- Revuforj is being used off-label in NPM1 and combination settings, with safety feedback positive.
- The company aims to be a leading specialty oncology company by 2030, with multiple commercial products and a robust pipeline.

Syndax Pharmaceuticals (SNDX)-3 Mar 25-2024 Q4 Earnings call transcript

Syndax Pharmaceuticals (SNDX)-5 Nov 24-2024 Q3 Earnings call transcript

Syndax Pharmaceuticals (SNDX)-1 Aug 24-2024 Q2 Earnings call transcript

Syndax Pharmaceuticals (SNDX)-8 May 24-2024 Q1 Earnings call transcript

- **Dual Regulatory Milestones**: Revumenib NDA submission under RTOR and axatilimab BLA with priority review (PDUFA: Aug 28, 2024). 
- **Commercial Expansion**: 2024 launch with 40-50 reps; $600M cash runway. 
- **Pipeline Growth**: Phase II IPF trial for axatilimab and Phase I colorectal cancer trial for revumenib. 
- **Market Opportunity**: $750M KMT2A AML market and 5,000 NPM1 AML patients. 
- **Financial Outlook**: 2024 OpEx $355-375M; ~$100M SG&A increase for sales force build.

**【CEO Summary Section】**
- **2023 Milestones**: Submitted NDA for revumenib under FDA's RTOR program for KMT2A acute leukemia and BLA for axatilimab in chronic GVHD with priority review (PDUFA: August 28, 2024). 
- **Commercial Strategy**: Planning 2024 launches with 40-50 reps covering both products; co-promoting axatilimab with Incyte (30% FTE contribution). 
- **Pipeline Expansion**: Phase II IPF trial for axatilimab and Phase I colorectal cancer trial for revumenib; exploring frontline AML combinations (revumenib + 7+3, venetoclax/azacitidine). 
- **Market Potential**: KMT2A AML ($750M US market) and NPM1 AML (~5,000 relapsed/refractory patients). 

**【CFO Financial Commentary】**
- **Q4 2023 Results**: $77.9M operating expenses ($55.1M R&D, $22.8M SG&A). 
- **2024 Guidance**: R&D $240-260M, OpEx $355-375M; $600M cash runway to 2026. 
- **Sales Force Build**: Hiring 40-50 reps for dual product coverage; ~$100M SG&A increase vs. 2023. 

**【Q&A Highlights】**
- **Launch Timing**: Revumenib PDUFA action date expected Q1; axatilimab launch Q3. 
- **Combo Trials**: Phase II 7+3 trial for frontline AML; Phase II axatilimab + ruxolitinib in chronic GVHD. 
- **IPF Trial Design**: 0.3mg/kg dose based on GVHD data; 135-patient trial targeting FVC decline. 
- **Safety Profile**: Revumenib no QTc prolongation; axatilimab minimal drug interactions. 
- **Colorectal Cancer**: Q2 2024 data readout for monotherapy activity in metastatic setting.

Actual												-0.56	-0.42	-0.46	-0.44	-0.54	-0.44	-0.4	1.81	-0.63	-0.62	-0.58	-0.62	-0.59	-0.64	-0.73	-1	-0.85	-0.8	-0.98	-1.1	-0.98	-0.83	-0.7	-0.78
Forecast												-0.4982	-0.4458	-0.4374	-0.4871	-0.6488	-0.7145	-0.1628	-0.5866	-0.635	-0.6367	-0.635	-0.6483	-0.5957	-0.7233	-0.7847	-0.9684	-0.9785	-0.9108	-1.0696	-0.8386	-1.2524	-1.0162	-0.7245	-0.584
Surprise	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	-12.40%	+5.79%	-5.17%	+9.67%	+16.77%	+38.42%	-145.70%	+408.56%	+0.79%	+2.62%	+8.66%	+4.37%	+0.96%	+11.52%	+6.97%	-3.26%	+13.13%	+12.17%	+8.38%	-31.17%	+21.75%	+18.32%	+3.38%	-33.56%

Actual	--	--	--	--	--	--	--	--	--	--	--	379.00K	379.00K	379.00K	380.00K	379.00K	379.00K	12.38M	126.58M	0	0	0	0	0	0	0	0	0	3.50M	12.50M	7.68M	20.04M	37.96M	45.87M	68.73M
Forecast	--	--	--	--	--	--	--	--	--	--	--	384.75K	390.00K	200.00K	100.00K	225.00K	225.00K	29.41M	6.29M	2.56M	1.38M	750.00K	1.33M	600.00K	0	0	0	0	0	9.32M	35.10M	16.47M	26.80M	48.03M	64.30M
Surprise	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%	-1.49%	-2.82%	+89.50%	+280.00%	+68.44%	+68.44%	-57.93%	+1911.80%	-100.00%	-100.00%	-100.00%	-100.00%	-100.00%	0.00%	0.00%	0.00%	0.00%	0.00%	+34.13%	-78.12%	+21.71%	+41.65%	-4.49%	+6.88%

SNDX

SNDX fundamentals

SNDX Q4 2025 Earnings

Earnings Call

You can ask Aime

SNDX

SNDX fundamentals

SNDX Q4 2025 Earnings

Earnings Call

SNDX Earnings Call Summary for Q4/20254:30 PM on Feb 26, 2026

SNDX Earnings Call Summary for Q3/20254:30 PM on Nov 3, 2025

SNDX Earnings Call Summary for Q2/20254:30 PM on Aug 4, 2025

SNDX Earnings Call Summary for Q1/20254:30 PM on May 5, 2025

SNDX Earnings Call Summary for Q4/20248:00 AM on Mar 3, 2025

You can ask Aime