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- **GABAB PAM for Cough**: IND-enabling studies ready; potential best-in-class efficacy with 70% cough reduction in preclinical models. 
- **Dipraglurant Repositioning**: Fast onset, short half-life; clinical studies preparation with Lund University/Sinntaxis. 
- **Stalicla Progress**: Autism patient stratification studies advancing; mavoglurant out-licensing and Series C financing in pipeline. 
- **Financial Sustainability**: CHF 2.2 million cash runway; external funding needed for unpartnered programs. 
- **Competitive Insights**: CCR5 modulators in stroke recovery trials (e.g., maraviroc) provide learnings for adaptive rewiring mechanisms. 
- **Indivior Milestones**: Up to USD 330 million in potential payments; royalty rates 5-10% on net sales. 


**【CEO Summary Section】**
- **Pipeline Progress**: Advanced GABAB PAM program for chronic cough, with IND-enabling studies ready to commence (subject to financing). Repositioned dipraglurant for post-stroke recovery, with preclinical profiling and clinical study preparation underway. Neurosterix's M4 PAM schizophrenia program nearing Phase I. Stalicla advancing patient stratification studies in autism spectrum disorders. 
- **Financial Update**: Q3 2025 cash balance of CHF 2.2 million, providing runway through mid-2026. Reduced cash burn post-Neurosterix spinout. Unpartnered programs require external funding for clinical progression. 
- **Collaboration Highlights**: Indivior completed IND-enabling studies for GABAB PAM in substance use disorders, with potential milestones worth up to USD 330 million. Exclusive license for mGlu5 inhibitors in brain injury recovery via Sinntaxis/University of Lund collaboration. 

**【CFO Financial Commentary】**
- **Revenue**: Q3 2025 income of CHF 0.1 million (patent maintenance and services). 
- **Expenses**: R&D (CHF 0.2 million), G&A (CHF 0.5 million), and equity method loss from Neurosterix (CHF 0.9 million). 
- **Balance Sheet**: Total assets CHF 7.4 million (cash CHF 2.2 million, noncurrent assets CHF 5 million). Liabilities stable at CHF 1.4 million. 

**【Q&A Key Highlights】**
- **Chronic Cough Market**: 50% of patients unresponsive to P2X3 inhibitors; GABAB PAM addresses central and peripheral mechanisms, with potential best-in-class efficacy. 
- **Stalicla Strategy**: Series C financing for Phase II studies in autism; mavoglurant out-licensing discussions. IPO considerations under evaluation. 
- **Stroke Recovery Competition**: CCR5 modulators (e.g., maraviroc) in CAMAROS trial; learnings from sensory/motor recovery endpoints to inform dipraglurant trial design. 
- **Indivior Collaboration**: IND submission for GABAB PAM in substance use disorders expected in 2026. Addex eligible for tiered royalties on net sales. 


Addex Therapeutics Ltd (ADXN) Q3 2025 Earnings Call Transcript

- **$65M Neurosterix Spin-Out:** CHF5M cash + 20% equity stake; removes financing overhang for core programs.
- **GABAB PAM Pipeline:**
  - Chronic cough candidate shows 30x safety margin; IND-enabling studies in 2025.
  - Indivior partner advancing substance use disorder program with IND in 2024.
- **Dipraglurant Repositioning:** Post-stroke recovery Phase 2a planned; preclinical data supports neuroplasticity benefits.
- **Financial Strength:** CHF3.3M cash runway to mid-2026; 20% stake in $65M-backed Neurosterix.

**【CEO Opening Remarks】**
- Launched Neurosterix with $65M Series A financing, securing CHF5M cash and 20% equity stake.
- Partnered with Indivior for GABAB PAM in substance use disorders, with IND-enabling studies underway.
- Regained rights to Phase 2 asset ADX-71149 from J&J, with 280kg API transferred for potential collaborations.
- 2024 cash balance: CHF3.3M, providing runway through mid-2026.

**【Mikhail Kalinichev - R&D Update】**
- **Dipraglurant (mGluR5-NAM):** Repositioned for post-stroke recovery; preclinical data shows improved neuroplasticity and functional recovery. IND-enabling studies planned.
- **GABAB PAM for Chronic Cough:** Preclinical efficacy (1mg/kg ED50) and tolerability superior to baclofen; IND-enabling studies to start in 2025.
- **Indivior Collaboration:** Selected GABAB PAM candidate for substance use disorders; IND-enabling studies initiated in H2 2024.

**【CEO Financial Review】**
- Continuing operations revenue: CHF0.4M (vs. CHF1.6M in 2023), driven by Indivior collaboration completion.
- R&D expenses: CHF0.9M (down 20% YoY); G&A: CHF2.3M (down 14% YoY).
- Net cash burn reduced post-Neurosterix spin-out; 20% equity stake in Neurosterix provides upside exposure.

**【Q&A Highlights】**
- **Neurosterix Structure:** 4 programs (M4 PAM, mGluR7-NAM, mGluR2-NAM, undisclosed CNS asset) focused on neuropsychiatry.
- **Dipraglurant Strategy:** Phase 2a planned to assess neuroplasticity modulation in post-stroke patients; potential for TBI applications.
- **ADX-71149 Future:** Exploring collaborations for unpartnered programs; high-quality dataset and materials available for repurposing.

Actual	-19.9139	-15.8164	-15.7834	-10.5033	-10.5119	-18.5267	-14.4602	-16.3027	-18.2713	-23.8906	11.4183	-27.5968	-5.367	-5.4936	-4.1145		-1.3452	11.3805	-2.6853			-3.0164	-1.4982
Forecast					-13.1291	-15.7515	-17.0538	-12.9835	-10.3265	-2.7059	-1.8564	-1.0314	-1.0314	-0.8251	-0.6623	-0.6623	-0.4415	-1.4239	-1.4197	-1.4197	-4.2591	0	0	0
Surprise	0.00%	0.00%	0.00%	0.00%	+19.93%	-17.62%	+15.21%	-25.56%	-76.94%	-782.91%	+715.08%	-2575.66%	-420.36%	-565.81%	-521.24%	0.00%	-204.69%	+899.25%	-89.15%	0.00%	0.00%	0.00%	0.00%	0.00%

ADXN

ADXN fundamentals

ADXN Q4 2025 Earnings Preview

Earnings Call

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ADXN

ADXN fundamentals

ADXN Q4 2025 Earnings Preview

Earnings Call

ADXN Earnings Call Summary for Q4/2025 Apr 8, 2026

ADXN Earnings Call Summary for Q3/20255:00 PM on Dec 4, 2025

ADXN Earnings Call Summary for Q2/20254:00 PM on Oct 1, 2025

ADXN Earnings Call Summary for Q1/20254:00 PM on Jun 19, 2025

ADXN Earnings Call Summary for Q4/202410:00 AM on Apr 25, 2025

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