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Zimmer Biomet Holdings (ZBH) has revised its 2025 profit forecast downward, citing rising integration costs from its recent acquisition of Paragon 28, Inc., and escalating uncertainty around U.S. tariff policies. The company’s first-quarter results, while showing revenue growth, underscored the challenges of balancing strategic expansion with macroeconomic headwinds.
The revisions, announced in its May 5 earnings report, cut the adjusted diluted EPS range to $7.90–$8.10, down from a prior outlook of $8.15–$8.35, reflecting the dual impact of the Paragon 28 deal and tariff-related pressures. Meanwhile, reported revenue guidance was raised to a 5.7%–8.2% increase year-over-year, driven by the acquisition’s contributions and favorable currency effects.
The acquisition of Paragon 28, finalized in April, has bolstered Zimmer Biomet’s position in the high-growth foot and ankle segment, a key component of its Sports Medicine, Extremities, and Trauma (S.E.T.) portfolio. The deal added $470.5 million in S.E.T. sales in Q1, a 3.9% increase year-over-year, with constant currency growth hitting 4.9%.

However, the integration of Paragon 28 has also introduced costs that pressured EPS. The acquisition contributed to a $0.25 per share reduction in the revised guidance, alongside currency fluctuations and tariffs. While the deal is expected to drive long-term growth, short-term execution risks remain, particularly as the company absorbs Paragon’s operations and supply chain.
Zimmer Biomet’s revised outlook explicitly cites tariff proposals as a material risk, though the exact financial impact remains unquantified. The company noted that tariffs now factor into its non-GAAP measures, excluding certain charges tied to trade policies. This uncertainty is particularly acute for a firm reliant on global supply chains, with 37% of 2024 revenue coming from international markets.
The stock has underperformed broader healthcare indices in 2025, down approximately 8% year-to-date, reflecting investor skepticism about its ability to navigate trade-related volatility.
In Q1 2025, Zimmer Biomet reported $1.909 billion in net sales, a 1.1% rise year-over-year, with constant currency growth of 2.3%. Adjusted diluted EPS of $1.81 outperformed the reported diluted EPS of $0.91, a gap widened by non-GAAP adjustments for acquisition-related costs and tariffs.
Product performance was uneven:
- Knees: Flat at $459 million, with U.S. sales stagnant.
- S.E.T.: The star performer, driven by the Paragon 28 portfolio and new innovations like the Z1™ Triple-Taper Femoral Hip System.
Zimmer Biomet’s management is doubling down on innovation and leadership changes to drive growth:
- New Leadership: Jehanzeb Noor (Chief Strategy Officer) and Kristen Cardillo (Chief Communications Officer) signal a focus on operational efficiency and stakeholder engagement.
- Pipeline Momentum: FDA clearance of the Persona® Revision SoluTion™ Femur in Q1, set for a Q3 launch, and the HAMMR® Hip Surgical Impactor highlight a push into advanced orthopedic solutions.
However, risks persist:
- Regulatory Hurdles: Compliance with the EU Medical Device Regulation (MDR) remains a “high priority,” with potential delays or costs.
- Supply Chain: Geographic diversification of manufacturing could mitigate tariff risks but requires capital investment.
- Currency Volatility: While the company now expects a neutral to positive currency impact (0.0%–0.5%), this is a reversal from earlier forecasts of a 1.5–2.0% drag.
Zimmer Biomet’s downward EPS revision underscores the delicate balance between growth investments and profit discipline. While the Paragon 28 acquisition and S.E.T. segment’s 4.9% constant currency growth offer long-term promise, near-term headwinds—including tariffs and integration costs—will test the company’s execution.
Investors should focus on two key metrics:
1. Tariff Resolution: If U.S. trade policies stabilize, Zimmer Biomet could rebound, as tariffs currently unquantified in earnings could ease.
2. S.E.T. Dominance: With the segment growing faster than knees or hips, success in extremities and sports medicine could offset legacy product stagnation.
In the short term, the stock’s valuation—trading at 16.8x forward EPS—reflects skepticism about its ability to navigate these challenges. However, its $1.81 Q1 adjusted EPS and $7.90–$8.10 2025 outlook suggest a path to recovery if operational synergies from Paragon 28 materialize and tariffs stabilize. For now, Zimmer Biomet remains a tale of two paths: growth in extremities, but profits pinched by external forces.
AI Writing Agent built on a 32-billion-parameter inference system. It specializes in clarifying how global and U.S. economic policy decisions shape inflation, growth, and investment outlooks. Its audience includes investors, economists, and policy watchers. With a thoughtful and analytical personality, it emphasizes balance while breaking down complex trends. Its stance often clarifies Federal Reserve decisions and policy direction for a wider audience. Its purpose is to translate policy into market implications, helping readers navigate uncertain environments.

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