Xeris Biopharma's Q2 2025: Navigating Contradictions in Recorlev Growth, Gvoke Strategy, and Margin Outlook

Generated by AI AgentEarnings Decrypt
Thursday, Aug 7, 2025 8:03 pm ET1min read
Aime RobotAime Summary

- Xeris Biopharma reported $72M Q2 2025 revenue (+49% YoY), driven by 46% growth in commercial products led by Recorlev.

- Recorlev revenue surged 136% to $31M with 122% patient therapy growth, leveraging its unique position in treating hypercortisolemia.

- Gvoke grew 17% to $23M with 5% prescription increase, while Keveyis maintained $11M revenue with stable patient numbers.

- Full-year 2025 guidance raised to $280-290M, reflecting strong demand for commercial products and execution confidence.

Recorlev market expansion and commercial infrastructure, Gvoke's growth and market strategy, gross margin and leverage, Recorlev market dynamics and growth potential, Recorlev writers expansion and growth expectations are the key contradictions discussed in Biopharma's latest 2025Q2 earnings call



Revenue Growth and Commercial Product Portfolio:
- reported total revenue of almost $72 million in Q2 2025, marking a 49% increase, with commercial product portfolio contributing $68 million, up 46%.
- The growth was driven by increased patient demand across all three products, particularly Recorlev's strong demand and differentiation as a treatment for hypercortisolemia and Cushing's syndrome.

Recorlev's Rapid Growth:
- Recorlev's revenue grew 136% year-over-year, reaching over $31 million in Q2 2025, with an average number of patients on therapy increasing by 122%.
- The expansion is attributed to its unique position as a needed treatment and strategic investments in healthcare professional engagement and patient support.

Gvoke Continued Growth:
- Gvoke's revenue was $23 million, a 17% increase from Q2 2024, supported by a 5% growth in prescriptions and some gross-to-net favorability.
- Steady prescription volume growth, driven by new and existing prescribers, and increased awareness of medical guidelines, contributed to its consistent performance.

Keveyis' Steady Performance:
- Keveyis' revenue was over $11 million in Q2 2025, demonstrating a modest increase in the average number of patients on therapy and growth in new patient starts.
- The performance reflects the strength of the Keveyis brand and the team's focus on execution in treating primary periodic paralysis patients.

Updated Revenue Guidance:
- Xeris raised its full-year 2025 revenue guidance to $280 million to $290 million, surpassing the previous range of $260 million to $275 million.
- The revision is based on the strong top-line performance and confidence in the growing demand for commercial products, particularly Recorlev.

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