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Vaxart’s Q1 2025 Call: A Critical Milestone for Oral Vaccine Innovation

Cyrus ColeFriday, May 2, 2025 8:10 am ET

14min read

Vaxart, Inc. (NASDAQ: VXRT) is set to host its first quarter 2025 business update and financial results conference call on May 13, 2025, marking a pivotal moment for the clinical-stage biotech firm. As investors await insights into the company’s financial trajectory and pipeline progress, the event promises to shed light on Vaxart’s ability to capitalize on its proprietary oral vaccine platform—a technology with the potential to redefine global vaccination strategies.

The Catalyst: Q1 2025 Call Details

The conference call, scheduled for 4:30 p.m. ET, will follow the release of Q1 2025 financial results after market close. Participants can access the live webcast via Vaxart’s website or by dialing domestic (877) 407-0832 or international (201) 689-8433 (Conference ID: 13753354). A replay will be available post-event, and investors may submit questions in advance to ir@vaxart.com by May 12. While specific financial metrics for Q1 2025 remain undisclosed, the call is expected to address:
- Clinical Pipeline Updates: Progress on Phase 2 trials for its norovirus and influenza vaccines, as well as its therapeutic HPV vaccine (an immune-oncology first-in-class candidate).
- BARDA Funding Impact: A $453 million award from the U.S. Biomedical Advanced Research and Development Authority (BARDA) to advance its oral COVID-19 vaccine through a Phase 2b trial.
- Financial Position: Cash reserves, R&D spending, and operational efficiency, especially as the company scales up manufacturing and clinical trials.

Why Vaxart’s Technology Matters

Vaxart’s core advantage lies in its oral recombinant vaccine platform, which delivers vaccines via pills that require no refrigeration—a stark contrast to traditional injectable vaccines. This innovation addresses critical challenges in global health, such as cold-chain dependency and needle-stick risks. The company’s pipeline includes vaccines targeting:
- Coronavirus: Including variants like XBB, with a focus on broad-spectrum protection.
- Norovirus: A Phase 2 trial in lactating mothers demonstrated safety and immunogenicity, underscoring the platform’s versatility.
- Influenza: A potential blockbuster opportunity if the oral formulation proves more effective than injectable alternatives.
- Therapeutic HPV: A first-in-class vaccine targeting cervical cancer, leveraging immune-oncology mechanisms.

The company’s patent portfolio, covering adenovirus-based delivery and TLR3 agonist adjuvants, further reinforces its technological edge.

Historical Performance and Analyst Outlook

While Q1 2025 specifics remain under wraps, historical data offers context:
- Q1 2024: EPS of $(0.14) beat estimates of $(0.16), with revenue of $2.18 million.
- Cash Position: As of December 31, 2024, Vaxart reported $101.7 million in cash, bolstered by a $40 million June 2024 underwritten offering.

Analysts project gradual financial improvement, with 2025 EPS estimates narrowing to $(0.40) from $(0.49) in 2024, reflecting higher R&D investment. Meanwhile, highlights its volatility, with investors likely awaiting catalysts like the Phase 2b trial results.

Risks and Opportunities

Clinical Trial Success: The upcoming Phase 2b trial for its oral COVID-19 vaccine, funded by BARDA, could validate the platform’s efficacy and open doors to government partnerships.
Manufacturing Scale: Cost efficiencies in pill production may improve margins versus traditional vaccines.
Competitor Landscape: While oral vaccines are rare, rivals like Pfizer and Moderna dominate the injectable space. Vaxart’s niche could carve a unique market if proven effective.

Conclusion: A High-Reward, High-Risk Play

Vaxart’s Q1 2025 call is a critical juncture for investors. The company’s oral vaccine platform addresses significant unmet needs in global health, and its BARDA-backed programs provide tangible near-term catalysts. However, success hinges on clinical trial outcomes, regulatory approvals, and operational execution.

With a $230 million market cap and a $100+ million cash runway, Vaxart has the financial flexibility to advance its pipeline. If the Phase 2b data for its oral COVID-19 vaccine meets expectations, the stock could see a significant rerating—potentially tripling in value if commercialized. Conversely, delays or setbacks could amplify volatility.

For long-term investors willing to tolerate risk, Vaxart represents a high-potential play in the $50 billion global vaccine market. The May 13 call will be the first test of whether the company can translate its innovative science into financial and clinical momentum. Stay tuned.

Final note: This analysis is based on publicly available data up to May 2, 2025. Actual Q1 2025 results may differ, and investors should consult the full earnings report and conference call transcript for detailed insights.

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