Top Penny Stocks to Watch in September 2025: Anixa Biosciences and Siebert Financial Lead the List

As the US stock market experiences a slight downturn, investors are watching the Federal Reserve's meeting for potential rate cuts. Penny stocks, often representing smaller or emerging companies, remain an intriguing segment of the market due to their affordability and growth potential. The top 10 penny stocks in the US include Dingdong, Waterdrop, WM Technology, Puma Biotechnology, and Performance Shipping, among others. Anixa Biosciences, a biotechnology company with a market cap of $96.61 million, is advancing its oncology-focused therapies and vaccines, while Siebert Financial Corp. is a brokerage firm with a market cap of $215.9 million.

The U.S. Federal Reserve is widely expected to deliver its first interest rate cut of the year at the conclusion of its two-day policy meeting on Wednesday, September 14, 2025 Federal Reserve set to begin rate cuts to provide relief against recession fears^[1]. This move comes amidst a slowing labor market and heightened recession fears, as President Donald Trump has repeatedly urged the Fed to lower rates.

Since December 2024, the Fed has held its benchmark rate between 4.25% and 4.50% while monitoring the effects of tariffs imposed under Trump’s protectionist trade policy on inflation. The CME Group’s FedWatch Tool shows that markets are now fully pricing in at least a 25-basis-point cut Federal Reserve set to begin rate cuts to provide relief against recession fears^[1].

The upcoming decision comes at a time of heightened political tension over the central bank’s independence. Trump’s confrontations with the Fed have included disputes over the cost of renovating its Washington headquarters and attempts to remove senior officials. In August, the president moved to dismiss Governor Lisa Cook over mortgage fraud allegations, while another vacancy was created by Governor Adriana Kugler’s resignation Federal Reserve set to begin rate cuts to provide relief against recession fears^[1].

Market attention will also be on Fed Chair Jerome Powell’s remarks about the outlook for inflation and future rate moves. While inflation pressures have eased compared to recent years, consumer price index data released last week showed a rise to 2.9% in August, the fastest pace so far this year. Economists at Wells Fargo cautioned that "the inflation genie has not quite been put back into the bottle" Federal Reserve set to begin rate cuts to provide relief against recession fears^[1].

As the US stock market experiences a slight downturn, investors are watching the Federal Reserve's meeting for potential rate cuts. Penny stocks, often representing smaller or emerging companies, remain an intriguing segment of the market due to their affordability and growth potential. The top 10 penny stocks in the US include Dingdong, Waterdrop, WM Technology, Puma Biotechnology, and Performance Shipping, among others.

Anixa Biosciences, a clinical-stage biotechnology company with a market cap of $96.61 million, is advancing its oncology-focused therapies and vaccines. The company's therapeutic portfolio includes an ovarian cancer immunotherapy program using a novel type of CAR-T technology, known as chimeric endocrine receptor-T cell (CER-T) Anixa Biosciences files for mixed shelf of up to $200 million - SEC filing^[2]. Its vaccine portfolio includes vaccines being developed in collaboration with Cleveland Clinic to treat and prevent breast cancer and ovarian cancer.

Another notable company in the penny stock segment is Siebert Financial Corp., a brokerage firm with a market cap of $215.9 million. Siebert Financial specializes in providing brokerage services to retail investors and small businesses.

The Federal Reserve’s rate cut decision is expected to have a significant impact on the broader market, including penny stocks. A reduction in interest rates could provide relief to companies by lowering borrowing costs, potentially boosting their growth and stock performance. However, the political tensions surrounding the Fed’s independence and the uncertain economic outlook could also introduce volatility.

Investors should closely monitor the Fed’s decision and subsequent remarks for any indications of future rate changes. Additionally, the performance of companies like Anixa Biosciences and Siebert Financial will be influenced by broader market trends and their individual progress in their respective sectors.