Tempus AI Shares Slide 2.7% as Trading Volume Plunges 68% to 166th Market Rank

On Sept. 12, 2025, , . , reflecting a notable reduction in market participation.

Recent developments suggest mixed market sentiment toward the stock. While no direct earnings reports or corporate actions were disclosed, the sharp volume contraction indicates potential profit-taking or strategic position adjustments by institutional investors. Analysts note that such liquidity shifts often precede short-term volatility, though no immediate catalysts have been identified in the public domain.

Back-testing analysis of a high-volume equity strategy highlights structural limitations in replicating a "top-500-by-volume" portfolio. Current tools are constrained to single-ticker strategies or event studies, necessitating alternative approaches like proxy ETFs or narrowed universes. For TEM specifically, this implies that volume-based momentum signals require external computational frameworks to execute effectively.

Three actionable pathways were outlined: leveraging broad-market ETFs as proxies, limiting testing to predefined indices like the S&P 500, or employing custom Python scripts for signal generation. Each approach carries trade-offs between accuracy and feasibility, with the latter option offering the highest fidelity but requiring external data integration.