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Third Rock Ventures, a major shareholder of Tango Therapeutics, sold nearly half a million shares on October 23, 2025, representing a 3.44% reduction in its direct ownership. The sale exceeded the historical median for sell-only transactions but was below the largest sale. The market context at the time of the transaction was a share price of approximately $10.15. The transaction did not significantly change Third Rock Ventures' ownership position, as it remains a major shareholder with a post-transaction value of approximately $100.8 million.

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