Quoin Pharmaceuticals, Ltd., was established by the laws of the State of Israel on August 4, 1986. Between 1986 and 2013, the company underwent several name changes, most recently on August 28, 2013, when the company changed its current name from T.R.F. Capital Ltd. The Company is a clinical stage specialty pharmaceutical company dedicated to the development and commercialization of therapeutic products for the treatment of rare and orphan diseases. The company's initial focus is to develop products using proprietary own and licensed drug delivery technologies that may help address rare inherited skin diseases, especially those for which there are currently no approved treatments or cures.