Spyre Therapeutics Sees 6 Expected Proof-of-Concept Readouts in 2026

Monday, Jan 12, 2026 9:04 am ET1min read
SYRE--

Spyre Therapeutics is poised for a transformative 2026 with six expected proof-of-concept readouts beginning in Q2. The SKYLINE trial for ulcerative colitis is recruiting faster than expected, with part A readouts now expected in Q2. The SKYWAY basket trial for rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis is on track, with all readouts expected in Q4. Kate Tansey Chevlen has been appointed Chief Commercial Officer, and the company has a strong balance sheet with a pro forma cash balance of $783M, providing cash runway into H2 2028.

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