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SOPHiA GENETICS Q4 2024: Navigating Contradictions in Biopharma Funding, Market Focus, and Geopolitical Challenges

Earnings DecryptTuesday, Mar 4, 2025 5:46 pm ET
1min read
These are the key contradictions discussed in SOPHiA GENETICS's latest 2024Q4 earnings call, specifically including: Biopharma Funding and Growth Expectations, U.S. Market Focus and Global Pipeline, Customer Volumes and ASP Assumptions, and Geopolitical Tensions and FX Volatility Impact:



Revenue and Market Growth:
- SOPHiA GENETICS reported revenue of $65.2 million for 2024, within the most recent guidance range, with a reported revenue growth rate below long-term expectations.
- Growth was driven by expansion in core genomic customers, new applications like MSK-ACCESS and MSK-IMPACT, and increased activity in the U.S. market.

Analysis Volume and Customer Expansion:
- Platform analysis volume increased by 11% year-over-year, reaching 352,000 patients in 2024.
- This increase was attributed to new applications and customer expansion, particularly in the U.S. market.

Financial Performance and Cost Management:
- Adjusted gross margin improved by 60 basis points to 72.8%, and adjusted operating loss improved by 20% year-over-year.
- Cost management efforts, including cloud compute optimizations, contributed to improved financial performance.

BioPharma Challenges and Opportunities:
- BioPharma-related revenue decreased by approximately $4 million in 2024 compared to the previous year.
- The decline was due to budget constraints and a shift towards centralized cost reductions, but potential opportunities exist for growth in future years.

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scccc-
03/04
SOPHiA's margins climbing, bullish vibes.
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Zurkarak
03/04
BioPharma slump temporary, diamond hands 🚀
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NoBicDeal
03/04
SOPHiA's cloud compute moves are slick. Margins up, costs down. Biopharma might be a bump, but long-term, they could pivot hard.
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kenton143
03/04
11% volume growth ain't shabby. New apps and U.S. expansion are the real MVPs. Keep an eye on those bio trends.
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InjuryIll2998
03/04
Cloud compute optimizations are lit.
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Very_Guilty_Lawyer
03/04
Revenue hit by BioPharma funding constraints, but long-term potential looks solid with expanding core genomic customers.
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Sugamaballz69
03/04
Revenue hit from bio constraints, but improved margins give hope. Holding $SOPH long, betting on their tech and market reach.
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