Silicon Valley's AI-Driven Health Twin Hits $950M Valuation, Reverses Diabetes in 71% of Users

Twin Health, a Silicon Valley-based startup specializing in AI-driven metabolic health solutions, has secured a $53 million Series E round, raising its valuation to over $950 million. The funding, led by Danish investment firm Maj Invest, marks a significant milestone for the company, which has been developing digital twin technology to combat type 2 diabetes and related metabolic disorders. This round also saw participation from existing investors Iconiq and Temasek [3]. The new capital will support the company’s expansion, particularly through partnerships with large employers and health plans, as it continues to scale its AI-powered health platform across the U.S. [3].

Twin Health’s digital twin technology, which creates a virtual replica of a user’s body to personalize health interventions, has shown promising results in clinical trials. A recent study led by the Cleveland Clinic and published in the New England Journal of Medicine Catalyst demonstrated that 71% of participants using Twin’s platform achieved an A1C level below 6.5%, effectively reducing their blood sugar to non-diabetic levels. Additionally, many participants were able to discontinue their use of glucose-lowering medications such as GLP-1 receptor agonists, SGLT-2 inhibitors, and insulin [3]. These findings highlight the potential of AI and machine learning to improve glycemic control and reduce long-term complications associated with diabetes, such as heart disease and kidney failure [4].

The Twin Precision Treatment system, at the heart of the company’s offering, integrates wearable sensors and a mobile app to deliver real-time health insights and personalized lifestyle recommendations. By continuously tracking metrics such as blood glucose levels, weight, activity, and sleep, the system generates tailored dietary and exercise guidance to help users reverse metabolic dysfunction. Dr. Lisa Shah, Twin Health’s chief medical officer, emphasized the importance of this precision medicine approach, stating that the study represents a critical step toward redefining the future of metabolic care [4].

Twin Health’s success is also reflected in the real-world experiences of users like Lyle Wallace, a pastor from Texas who was diagnosed with diabetes in 2023. Using Twin’s digital twin technology, Wallace reduced his A1C to 5.1 within 90 days and was able to stop taking Metformin. He also lost 70 pounds over a few months, crediting the platform with helping him regain control over his health [3]. These outcomes underscore the growing interest in technology-driven solutions to address the complex interplay between biology and behavior in metabolic health.

The company, founded in 2018 by Jahangir Mohammed, a former founder of Jasper Technologies, is positioned to capitalize on the increasing demand for innovative diabetes management tools. With nearly 50 million Americans affected by diabetes, the market for effective interventions is vast. Twin’s approach, which focuses on reversing the condition through AI-powered insights rather than merely managing symptoms, aligns with a broader shift in healthcare toward prevention and personalized treatment [3]. The company’s partnerships with health plans and corporate clients, including Benjamin Moore and Health Care Service Corporation, indicate strong commercial traction and a potential for widespread adoption in the coming years [3].

Source:

[1] Twin Health - Partner with Twin (https://usa.twinhealth.com/request-a-meeting)

[2] Twin Health on the App Store (https://apps.apple.com/us/app/twin-health/id1456423142)

[3] Exclusive: Twin Health, metabolic health startup, raises ... (https://fortune.com/2025/08/21/exclusive-twin-health-metabolic-health-startup-raises-53-million-series-e-at-950-million-valuation/)

[4] New Peer-Reviewed Study in New England Journal of ... (https://finance.yahoo.com/news/peer-reviewed-study-england-journal-210000327.html)