Short Interest in S&P 500 Healthcare Sector Decreases in July; Moderna Remains Most Heavily Shorted Stock

Saturday, Aug 16, 2025 9:26 pm ET1min read

Short bets on the S&P 500 Healthcare sector eased slightly in July to 1.95% from 1.96% in June. Moderna remains the sector's most heavily shorted stock. Despite the overall decrease, Moderna's short interest remains high due to concerns about its vaccine efficacy and market competition.

The average short interest in the S&P 500 Health Care Index Sector (NYSEARCA:XLV) dipped slightly in July to 1.95% from 1.96% in June. However, Moderna (NASDAQ:MRNA) held its position as the sector's most heavily shorted stock, despite the overall decrease. This trend reflects ongoing concerns about Moderna's vaccine efficacy and market competition.

Moderna's short interest as a percentage of its float has fallen 4.88% since its last report, according to Benzinga. As of the latest data, 22.63% of all regular shares available for trading are sold short, which would take traders an average of 8.24 days to cover their positions. This decrease in short interest does not necessarily indicate a near-term price increase but signals a shift in market sentiment towards the company.

The sector's overall decrease in short interest is likely influenced by broader market trends and the overall health of the healthcare sector. However, Moderna's persistent high short interest highlights specific concerns about its vaccine efficacy and market competition. The company's recent financial reports and market performance have been closely watched, with investors and analysts questioning the long-term viability of its mRNA-based vaccine technology.

The U.S. government's recent cancellation of $500 million worth of Biomedical Advanced Research and Development Authority (BARDA) contracts around mRNA vaccine research has also contributed to the negative sentiment surrounding Moderna and mRNA technology. Health Secretary Robert F. Kennedy Jr. has been vocal in his opposition to mRNA vaccines, claiming they fail to protect effectively against upper respiratory infections like COVID and flu. However, this claim lacks scientific evidence, and prominent figures in the public health community have criticized Kennedy's stance.

Despite the challenges faced by Moderna, the company continues to invest in its mRNA technology and expand its portfolio of products. The recent decrease in short interest suggests that some investors are becoming more optimistic about the company's future prospects. However, the ongoing debate surrounding mRNA vaccines and the broader healthcare sector will likely continue to influence market sentiment and short interest.

References:
1. [https://seekingalpha.com/news/4485246-short-bets-on-sp-500-healthcare-sector-ease-in-july-moderna-remains-most-heavily-shorted-stock](https://seekingalpha.com/news/4485246-short-bets-on-sp-500-healthcare-sector-ease-in-july-moderna-remains-most-heavily-shorted-stock)
2. [https://www.biospace.com/policy/rfk-jr-creates-more-vaccine-misinformation-with-mrna-cancellations](https://www.biospace.com/policy/rfk-jr-creates-more-vaccine-misinformation-with-mrna-cancellations)
3. [https://www.benzinga.com/insights/short-sellers/25/08/47065620/whats-driving-the-market-sentiment-around-moderna](https://www.benzinga.com/insights/short-sellers/25/08/47065620/whats-driving-the-market-sentiment-around-moderna)

Short Interest in S&P 500 Healthcare Sector Decreases in July; Moderna Remains Most Heavily Shorted Stock

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