Senti Biosciences Publishes Research in Cell Systems Demonstrating Advanced Logic-Gated CAR Design for Cell Therapies.

Senti Biosciences published a study in Cell Systems demonstrating its advanced logic-gated CAR design for cell therapies. The study shows that NOT-gated chimeric antigen receptor circuits in T cells and NK cells can significantly improve efficacy, precision, and safety by selectively eliminating tumor cells while sparing healthy tissue. The research provides a systematic framework for engineering NOT-gated CAR circuits and identifies inhibitory CARs based on the LIR1 receptor as potent regulators of immune cell activity.