SenesTech shares fall 20.35% after-hours amid mixed Q4 results, ongoing net losses, and CEO transition uncertainty.

SenesTech Inc. fell 20.35% in after-hours trading following the release of its 2025 financial results, which highlighted mixed operational and financial performance. While revenue rose 20% to $2.2 million driven by e-commerce growth (up 88% year-over-year), the company reported a $6.4 million net loss, including $631,000 in one-time legal expenses and $135,000 in non-cash lease costs. Adjusted EBITDA loss narrowed to $5.3 million from $5.8 million in 2024, but the transition to direct Amazon sales management—a strategic move expected to boost margins—resulted in a $200,000 fourth-quarter revenue hit. The report also noted a CEO transition and ongoing losses despite improved gross margins. Investors appeared to focus on the persistent net losses, transition costs, and uncertainty around leadership changes, overshadowing positive e-commerce momentum and margin improvements.