Semler Scientific Boosts Bitcoin Holdings by 455 BTC, 25.8% Yield in 2025

Semler Scientific, a Nasdaq-listed medical technology and software company based in California, has significantly bolstered its Bitcoin holdings. The company recently acquired an additional 455 BTC, marking its third-largest purchase since adopting a Bitcoin standard approximately one year ago. This acquisition was made between May 13 and May 22, 2025, at an average purchase price of $109,801 per coin, totaling $50 million. The funds for this purchase were derived from the company's $500 million at-the-market offering program, under which 3,003,488 shares have been issued, generating $114.8 million in proceeds.

With this latest purchase, Semler Scientific now holds a total of 4,264 BTC, valued at approximately $474.4 million. The company has spent a total of $390 million on Bitcoin, with an average cost basis of $91,471 per coin. This aggressive acquisition strategy mirrors that of Strategy, formerly known as MicroStrategy, and its Chairman, Michael Saylor, who is a prominent advocate for Bitcoin.

Semler Scientific's Bitcoin yield, a performance indicator popularized by Saylor and Strategy, has increased to 25.8% in 2025. This yield is calculated as the ratio of the company's Bitcoin holdings to its assumed diluted shares outstanding. With 4,264 BTC, Semler Scientific's Bitcoin treasury ranks 13th in size among publicly traded companies.

The trend of companies incorporating Bitcoin into their treasuries has been growing. Strategy, a software intelligence company, began purchasing BTC in 2020 under the leadership of former CEO Michael Saylor. Since then, the company has accumulated a substantial amount of Bitcoin, valued at approximately $62 million at current prices. This trend has been followed by over 70 firms, including notable names such as Cantor Fitzgerald, SoftBank, Bitfinex, and Tether, which recently announced a $3.6 billion Bitcoin venture called Twenty One. Other companies, such as Japanese investment firm Metaplanet, have also adopted similar strategies, continuing to acquire the world's oldest and largest cryptocurrency.