Sartorius Unveils Octet R8e System for Advanced Biomolecular Interaction Analysis

Sartorius launches the Octet R8e biolayer interferometry (BLI) system, providing researchers with advanced detection capabilities for real-time, high-throughput analysis of protein-protein and biomolecular interactions. The system offers higher sensitivity, flexible assay design, and longer run times, expanding the industry-leading fluidic-free Octet BLI portfolio. It is designed for applications requiring higher sensitivity, flexible assay design, and longer run times.

Sartorius AG, a leading life science company, has launched the Octet R8e biolayer interferometry (BLI) system, marking a significant advancement in real-time, high-throughput analysis of protein-protein and biomolecular interactions. The new system expands Sartorius' industry-leading fluidic-free Octet BLI portfolio, offering enhanced sensitivity, flexible assay design, and extended run times [1].

The Octet R8e system leverages Sartorius' proprietary BLI technology, providing next-level sensitivity for accurate data generation at the lowest detection limits. This allows for the analysis of low-molecular weight ( 100 Da) and low-abundance (10 pM) analytes, broadening the dynamic range and improving detection limits [1]. Compatibility with 96- and 384-well plate formats offers additional flexibility in assay design, enabling customization to each study's unique scale, complexity, and cost requirements [1].

A notable feature of the Octet R8e is its advanced evaporation control in the 96-well plate format. This innovation preserves sample integrity, allowing for extended runtimes of up to 16 hours. The new evaporation cover minimizes sample evaporation, ensuring accurate measurements over extended assay durations without manual intervention [1].

Nilshad Salim, Product Manager of Octet® Systems at Sartorius, highlighted the system's capabilities: "The combination of high sensitivity and the ability to reduce sample size to 40 μL with our custom 384-well microplates gives researchers maximum freedom and significant cost efficiencies, without sacrificing data quality" [1]. The advanced evaporation protection is a game changer, supported by data showing excellent reproducibility between replicates over 16-hour experiments [1].

The Octet R8e system is designed to accelerate biopharmaceutical research across various stages, from drug discovery to development, bioprocessing, and quality control. With a large global install-base in regulated environments across pharma, biotech, and CRO organizations, the Octet R8e offers a powerful and streamlined alternative to SPR-based platforms [1].

References:
[1] https://www.sartorius.com/en/company/newsroom/product-news/sartorius-launches-the-octet-r8e-system-real-time-label-free-biomolecular-interaction-analysis-with-unprecedented-sensitivity-and-efficiency-1690702
[2] https://www.news-medical.net/news/20250524/Sartorius-launches-the-Octetc2ae-R8e-System-Real-time-label-free-biomolecular-interaction-analysis-with-unprecedented-sensitivity-and-efficiency.aspx