Sarepta Therapeutics Reports Strong 2024 Performance, Exceeds Guidance

Sarepta Therapeutics, a leader in precision genetic medicine for rare diseases, reported preliminary* fourth quarter and full-year 2024 net product revenue, marking a significant year for the company and its patients. The company's exceptional performance was highlighted by Doug Ingram, president and chief executive officer, who stated, "2024 marked the most significant year to date for Sarepta and for the patients we serve."

The company's total net product revenue for the fourth quarter of 2024 was $638.2 million, representing a 75% year-over-year growth. This impressive figure was driven by the robust performance of ELEVIDYS, which grew by a very robust 112% over the prior sequential quarter, overachieving guidance by more than $60 million. The company's 2024 total net product revenue grew by 56% over 2023, demonstrating a strong track record of execution and growth.



ELEVIDYS, a single-dose, adeno-associated virus (AAV)-based gene transfer therapy, played a significant role in the company's success. The drug, indicated for the treatment of Duchenne muscular dystrophy (DMD) in individuals at least 4 years of age, generated $384.2 million in net product revenue for the fourth quarter and $820.8 million for full-year 2024. Despite the strong launch of ELEVIDYS, Sarepta's PMO franchise continued to perform and grow year-over-year, generating $254.0 million and $967.2 million in net product revenue for the fourth quarter and full-year of 2024, respectively.

The company's preliminary year-end 2024 cash, cash equivalents, restricted cash, and investments balance was approximately $1.5 billion. This substantial cash position reflects the company's strong financial health and ability to invest in its pipeline and future growth.

Sarepta Therapeutics reiterated its 2025 full-year total net product revenue guidance of $2.9 to $3.1 billion, indicating its confidence in maintaining its growth trajectory. The company's exceptional performance in 2024, driven by the strong launch of ELEVIDYS and the continued growth of its PMO franchise, positions it well for continued success in the coming years.

In conclusion, Sarepta Therapeutics' preliminary* fourth quarter and full-year 2024 net product revenue report highlights the company's strong performance and growth potential. With a robust pipeline, a diverse portfolio of products, and a track record of execution, Sarepta Therapeutics is well-positioned to continue delivering value to its shareholders and patients in the years to come.