Regeneron Shares Plummet 0.64% as Trading Volume Dips to $310M 30.93% Below Prior Day Stock Ranked 394th in Activity Amid COPD Trial Update

On July 30, 2025, Regeneron Pharmaceuticals (REGN) closed with a 0.64% decline, marking a drop in trading volume to $310 million—a 30.93% decrease compared to the previous day. The stock ranked 394th in trading activity among listed equities. The move followed recent updates on a Phase 4 clinical trial led by Regeneron and Sanofi, focusing on Dupilumab for chronic obstructive pulmonary disease (COPD). The study, designed to evaluate airway inflammation and lung function in patients aged 40–85, employs a randomized, double-blind, placebo-controlled model with quadruple masking. With an estimated start date of September 15, 2025, the trial’s progression could shape investor sentiment in the long term, particularly as COPD therapies remain a competitive pharmaceutical sector.

The collaboration highlights Regeneron’s strategic focus on expanding Dupilumab’s therapeutic applications beyond existing indications. While the trial is not yet recruiting, the July 28 update underscores the companies’ commitment to advancing the drug’s potential in respiratory medicine. Analysts note that positive outcomes could strengthen Regeneron’s market position, though near-term volatility may persist due to the trial’s early-stage status. The study’s emphasis on lung imaging parameters and mucus plugging aligns with unmet medical needs in COPD treatment, potentially differentiating Dupilumab in a crowded therapeutic landscape.

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