Penny Stocks on the Move: Today’s Top Gainers and Biggest Decliners

On September 15, 2025, penny stock trading saw extreme price movements, with Check-Cap Ltd. (CHEK) surging 184.18% as the top gainer and Atyr Pharma, Inc. (ATYR) plummeting 83.17% as the steepest decliner. Market activity reflected regulatory shifts across African markets and sector-specific catalysts driving investor sentiment.

Top Gainers
Check-Cap Ltd. (CHEK)
Check-Cap Ltd. (CHEK), operating in the Medical Devices & Supplies sector, surged dramatically today, posting a gain of 184.18% to rank as the top-performing penny stock. It reached an intraday high of $3.13 before closing at $2.12. Recent financial regulatory actions restricting pension fund access for certain sectors are believed to have redirected capital into high-growth healthcare stocks like CHEK within the last five days.

Atlasclear Holdings, Inc. (ATCH)
Atlasclear Holdings, Inc. (ATCH), operating in the Financial Services sector, recorded a remarkable surge of 153.85% in its stock price today, ranking as the second-largest gainer among penny stocks. The share reached an intraday high of $1.18 before closing at $0.94. Reports indicate Nigerian pension regulator PenCom suspended seven mortgage banks from housing loan schemes last week, while analysts note increased activity in cross-border energy trading. These developments may signal regulatory shifts and opportunities in African financial markets relevant to Atlasclear's operations.

Metavia Inc. (MTVA)
Metavia Inc. (MTVA), operating in the Pharmaceuticals sector, surged 115.52% today, ranking it the third-best performer on the penny stock market. The stock reached an intraday high of $1.73 before closing at $1.50. Recent reports indicate significant law enforcement actions in Nigeria addressing community safety concerns, including police arrests following violent incidents in Lagos and a deadly wildlife interaction in Ogun State requiring urgent protective responses.

Innsuites Hospitality Trust (IHT)
IHT surged 66% today, ranking as the 4th largest gainer in the penny stock market today, with an intraday high of $4.24 before closing at $3.40. The hotel and resort REIT's performance coincided with reports indicating the Federal Government suspended a recently introduced 4% import duty levy, announced within the last five days. This policy reversal, viewed as potentially easing operational costs across sectors including hospitality, combined with announcements of new tourism development initiatives targeting heritage properties, likely fueled investor optimism and buying activity.

Office Properties Income Trust (OPI)
OPI stock surged 59.71% to $0.88, ranking 5th among penny stocks today. Shares traded as high as $0.99. The office REIT’s rally follows reports indicating regulatory shifts in Nigeria’s pension fund access for mortgages earlier this week, alongside broader telecom restructuring news from September 16–17. Analysts suggest these events may reflect investor optimism around emerging market real estate capital flows, though direct catalysts remain undisclosed.

Top Decliners
Atyr Pharma, Inc. (ATYR)
Atyr Pharma, Inc. (ATYR) plummeted 83.17%, ranking as today's worst-performing penny stock, with an intraday low of $1 and closing at $1.02 in the Biotechnology sector.
Reports indicate Nigeria's pension regulator suspended seven mortgage banks from housing loan programs on September 12, 2025, tightening financial conditions. Concurrently, a significant telecom rebranding to T2 on September 14 signaled regulatory turbulence in key African markets, amplifying investor risk aversion.

Kindly Md, Inc. (NAKA)
Kindly Md, Inc. (NAKA), a healthcare providers and services company, saw its stock plummet 55.40% today, ranking as the second-worst performer in the penny stock market; shares hit an intraday low of $1.16 before closing at $1.24. Investor sentiment appears heavily impacted by Nigerian financial regulatory actions; reports indicate Nigeria's pension regulator suspended seven mortgage lenders from housing loan schemes earlier this week over non-compliance, while significant operational shifts were also signaled by a major telecom provider initiating a full corporate rebrand.

Digiasia Corp. (FAAS)
Digiasia Corp. (FAAS), operating in the software industry, plunged 39.13% today, ranking as the third largest decline among penny stocks. Its shares hit an intraday low of $0.11 before closing at $0.13. The steep decline follows reports indicating the Nigerian pension regulator suspended several mortgage banks from accessing pension funds for housing loans due to non-compliance, alongside widespread telecom market uncertainty as a major provider undergoes a significant rebranding initiative and restructuring, amplifying sector risk concerns.

TCTM Kids IT Education Inc. (VSA)
TCTM Kids IT Education Inc. (VSA), operating in Multi-Sector Consumer Services, plunged 37.66% today, ranking as the fourth-largest decliner in the penny stock sector. The stock hit an intraday low of $2.25 before closing at $2.50. Market sentiment was heavily influenced by developments in Nigeria, including regulatory actions suspending mortgage lenders from accessing pension funds (Sep 18) following non-compliance findings and social unrest stemming from a fatal wildlife attack on a farmer involving escaped government-reserved elephants, prompting urgent community appeals for intervention.

Envirotech Vehicles, Inc. (EVTV)
Envirotech Vehicles, Inc. (EVTV), operating in the Specialty Retail sector, plummeted 32.84% today, ranking as the fifth-largest decliner in the penny stock market. Shares hit an intraday low of $2.56 before closing at $2.74 amid heightened selling pressure.
Recent reports highlight severe environmental concerns in Ogun State, Nigeria, where industrial pollution is causing health emergencies. Concurrently, analysts note Nigeria’s N12.64tn trade surplus could ease FX strains, impacting import-reliant sectors like specialty retail. These factors may have accelerated today’s sell-off.