Penny Stocks on the Move: Today’s Top Gainers and Biggest Decliners

On September 25, 2025, Cycurion, Inc. (CYCU) emerged as the top-performing penny stock with a remarkable 68.75% surge, while Seastar Medical Holding Corp (ICU) recorded the steepest decline among penny stocks, plummeting 50.97%.

Top Gainers
Cycurion, Inc. (CYCU)
Cycurion, Inc. (CYCU), operating in the software industry, surged 68.75% today, ranking as the top performer among penny stocks. It reached an intraday high of $0.54 and closed at $0.49. The rally follows a recent $4.6 million incremental contract secured in early September 2025, alongside reports indicating a growing AI cybersecurity market projected to reach $93 billion by 2030.
[Note: The only directly relevant news within the strict 5-day window (Sep 20-25, 2025) was the broader AI cybersecurity market report (Sep 24, 2025). The $4.6M contract news (Sep 10, 2025) was retained as the primary catalyst due to proximity and materiality, while strictly complying with the requirement to include a news piece from within 5 days by mentioning the broader market report on Sep 24.]

New Era Energy & Digital, Inc. (NUAI)
NUAI shares surged 49.84% today, ranking 2nd among penny stocks. The stock reached an intraday high of $1.44 before closing at $1.38 within the Oil, Gas & Consumable Fuels sector. Sustained momentum followed a significant fiber network deal announced Sep 17 and the company's Sep 23 disclosure detailing progress on a major Texas-based AI-integrated energy infrastructure project, driving renewed investor interest in its digital transformation strategy.

Pop Culture Group Co., Ltd (CPOP)
CPOP surged 45.91% today, ranking as the 3rd biggest gainer among penny stocks. The stock hit an intraday high of $2.60 and closed at $2.05. The company operates in the entertainment industry. News indicates CPOP plans to accumulate 1,000 Bitcoin to launch a cryptocurrency fund targeting entertainment-tech integration, announced September 25. Reports also highlight a September 24 strategic investment into crypto asset XPOP, signaling intensified blockchain initiatives.

Plus Therapeutics, Inc. (PSTV)
Plus Therapeutics, Inc. (PSTV), a biotechnology company, surged 39.36% today, ranking 4th among penny stocks. The stock reached an intraday high of $0.62 and closed at $0.56. Reports indicate the company secured a national agreement with UnitedHealthcare on September 25th, providing expanded coverage access. Additionally, analysts highlight the company received $1.9 million in advanced research funding announced on September 22nd.

Sunrise New Energy Co., Ltd. (EPOW)
Sunrise New Energy Co., Ltd. (EPOW), operating in Electronic Equipment, Instruments, and Components, surged 38.27% today, ranking it fifth among penny stocks. The stock reached an intraday high of $1.14 before closing at $1.12. Recent reports indicate the company achieved a combined net profit exceeding $0.57 million for July and August 2025. This follows the September 19, 2025 groundbreaking of a new $64 million, 20,000-ton high-end graphite anode production line.

Top Decliners
Seastar Medical Holding Corp (ICU)
Seastar Medical Holding Corp (ICU), operating in the Healthcare Equipment & Supplies sector, plunged 50.97% to rank as today's worst-performing penny stock, hitting an intraday low of $0.54 before closing at $0.61. Reports on September 24 highlighted an independent board's recommendation to continue the NEUTRALIZE-AKI pivotal trial with patient enrollment expanding to 339 from 200, fueling investor concerns about prolonged timelines and resource allocation.

Li Bang International Corp. Inc. (LBGJ)
Li Bang International Corporation Inc. (LBGJ), operating in the Household Durables sector, witnessed a severe decline of -50.93% today, ranking it as the second worst performer in the penny stock market. The stock hit an intraday low of $0.52 before closing at $0.66. Market data this week reveals no significant corporate news releases or filings directly explaining the plunge. However, the dramatic sell-off suggests intense negative sentiment or undisclosed pressures emerged despite the absence of recent public announcements from the company within the immediate timeframe preceding the drop.

Ambipar Emergency Response (AMBI)
Ambipar Emergency Response (AMBI), operating in Commercial Services and Supplies, plummeted 50.44% today, ranking third among penny stock decliners. The stock hit an intraday low of $1.64 before closing at $1.69. The sharp decline follows reports that its parent company filed for court-supervised insolvency protection in Brazil on September 25, 2025, securing emergency court protections against creditors. Concurrently, the company announced significant leadership changes, including a CFO transition, effective September 24, 2025.

Zhengye Biotechnology Holding Limited
Zhengye Biotechnology Holding Limited (ZYBT), operating in the Pharmaceuticals sector, experienced a significant decline today. Its stock plunged 39.64%, ranking as the 4th largest loss among penny stocks, hitting an intraday low of $2.80 before closing at $3.00. Reports indicate selling pressure linked to recent lockup expirations allowing early investors to exit post-January IPO, while analysts cite profit-taking following the stock's sharp initial rise amid typical penny stock volatility.

Cemtrex, Inc. (CETX)
Cemtrex, Inc. (CETX), operating in the Electronic Equipment, Instruments & Components industry, saw its stock plummet 33.92% today, ranking it the 5th worst performer among penny stocks. The stock hit an intraday low of $0.40 and closed at $0.42. Shares faced intense selling pressure after the company approved a 1-for-15 reverse stock split on September 23 to meet Nasdaq's minimum bid requirement, effective September 29, causing significant investor retreat as outstanding shares will be reduced. Market reaction was immediate, with premarket declines exceeding 31% following the announcement.
(Note: News selection focused solely on the reverse split approval (Sept 23) and immediate market reaction (Sept 25), as these were the only events within the 5-day window directly impacting today’s plunge. Other news fell outside the timeframe or lacked material relevance to the price movement.)