Penny Stocks on the Move: Today’s Top Gainers and Biggest Decliners

On May 16, 2025, the penny stock market witnessed notable fluctuations with Affimed N.V. experiencing the most significant increase, surging by an impressive 228.24%. Conversely, Healthcare Triangle, Inc. faced the steepest decline, plummeting by 78.95%. This dynamic trading day highlighted both optimism and volatility within the penny stock sector.

Top Gainers
Affimed N.V. (AFMD)
Affimed N.V., a pharmaceutical company, witnessed a staggering 228.24% increase in its stock today, marking the highest change among penny stocks. The stock reached an intraday high of $0.573 before closing at $0.279. Reports indicate Affimed received a Nasdaq delisting notice on May 14, 2025, following insolvency filings, while analysts say the acceptance of abstracts for the ASCO meeting has driven optimism.

Inozyme Pharma, Inc. (INZY)
Inozyme Pharma, Inc., a biotechnology company, saw a remarkable stock increase of 178.17% today, ranking second among penny stocks. The intraday high reached $3.96, closing at $3.95. Reports indicate BioMarin's acquisition of Inozyme for $270 million on May 16, 2025, has largely driven the surge, alongside the release of strong Q1 2025 financial results on May 14, 2025.

Siyata Mobile Inc. (SYTA)
Siyata Mobile Inc., a key player in the radio telecommunications industry, witnessed a remarkable 75% surge in its stock today, ranking third among penny stocks. The company's intraday high reached $3.2, closing at $2.31. Reports indicate that the company's strategic relocation of its manufacturing operations to the U.S., announced on May 15, 2025, is seen as a pivotal move to boost sales, while the recent release of its Q1 2025 financial results has strengthened investor confidence.

Lazydays Holdings, Inc. (GORV)
Lazydays Holdings, Inc., a prominent player in the specialty retail sector, experienced a significant stock price surge of 56.43% today, ranking fourth among penny stocks. The stock reached an intraday high of 0.471, closing at 0.219. Recent reports indicate that Lazydays announced its first-quarter 2025 financial results on May 15, 2025, revealing strategic initiatives and operational improvements that have bolstered investor confidence and contributed to the remarkable stock performance.

Amesite Inc. (AMST)
Amesite Inc., a player in the Interactive Media and Services industry, saw its stock price skyrocket by 50% today, ranking 5th in the penny stock market. The stock hit an intraday high of $4.07 before closing at $3.36. Recent reports on May 16, 2025, highlight Amesite's unveiling of an advanced enterprise version of NurseMagic, alongside a new partnership with National Industry Results Inc., fueling a trading surge of over 50%.

Top Decliners
Healthcare Triangle, Inc. (HCTI)
Healthcare Triangle, Inc. experienced a significant decline in its stock price today, plummeting by 78.95%, marking the largest drop in the penny stock market. The company's intraday low was $0.007, closing at $0.008. As a digital transformation solutions provider in the software industry, recent reports indicate that the announcement of a $15.2 million private investment in public equity PIPE offering on March 3, 2025, coupled with Spartan Capital Securities' completion update, has contributed to heightened market volatility. Analysts say the integration of AI TRiSM Framework for healthcare security management has failed to reassure investors, further impacting stock performance.

Logprostyle Inc. (LGPS)
Real estate management and development company Logprostyle Inc. experienced a drastic drop in its stock today, declining by 59.38%, ranking it second in today's penny stock market for the biggest loss. The stock hit an intraday low of $1.07 and closed at $1.105. Recent reports indicate that on May 13, 2025, the company's initial public offering pricing at $5.00 per share faced scrutiny, which, coupled with the market's uncertainty about the company's business expansion plans announced on May 15, 2025, has contributed to today's dramatic stock plunge.

Lianhe Sowell International Group Ltd (LHSW)
Today, Lianhe Sowell International Group Ltd experienced a significant stock drop of 54.05%, ranking third among today's penny stock market movers. The intraday low was $1.28 with a closing price of $1.36. Operating in the software industry, recent reports indicate that Lianhe Sowell International Group filed for a 2,000,000 share IPO at $4-$5 per share on May 16, 2025, and received a non-binding letter concerning its technology solutions on May 12, 2025, contributing to today's stock plunge.

Click Holdings Limited (CLIK)
Click Holdings Limited (CLIK), a fast-growing human resources solutions provider in the professional services industry, experienced a significant market downturn today, with shares plummeting by 32.54%. This decrease positioned CLIK as the fourth worst performer among penny stocks. The stock hit an intraday low of 0.443 before closing at 0.479. Reports indicate that despite the recent cooperation agreement with Flash Mutual announced on May 15, 2025, investor concerns about potential future funding needs and scaling challenges contributed to today's dramatic plunge in share value.

Origin Materials, Inc. (ORGN)
Origin Materials, Inc., a player in the chemical products industry, saw its stock drop by a staggering 31.99% today, ranking fifth in the penny stock market decline. The company's shares hit an intraday low of $0.40 before closing at $0.44. Reports indicate that on May 15, 2025, Origin Materials released its Q1 2025 earnings, missing forecasts with an EPS of -$0.18, further contributing to the market plunge. Analysts say the company's outlined revenue goals for 2027 may not suffice to counteract investor concerns following the earnings miss.