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On June 10, 2025, Nucana's stock surged by 53.95% in pre-market trading, marking a significant rise that has caught the attention of investors and analysts alike.
Nucana plc, a UK-based clinical-stage biopharmaceutical company, is dedicated to enhancing treatment outcomes for cancer patients through its innovative ProTide technology. The company's pipeline includes several promising candidates, such as NUC-3373 and NUC-7738. NUC-3373, a ProTide transformation of the active anti-cancer metabolite of 5-fluorouracil (5-FU), has shown potential in Phase I and Phase Ib/II clinical trials for advanced solid tumors and colorectal cancer, respectively. Similarly, NUC-7738, a ProTide transformation of 3â-deoxyadenosine (3â-Da), is being evaluated in a Phase I/II clinical trial for advanced solid tumors. Additionally, Acelari, a ProTide transformation of the nucleoside
gemcitabine, is part of the company's pipeline.Nucana's recent presentation highlighted the company's commitment to advancing its clinical trials and bringing innovative cancer treatments to market. The positive market response to this presentation suggests that investors are optimistic about the company's prospects and the potential of its ProTide technology to revolutionize cancer treatment.

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