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Novo Nordisk's Semaglutide Trials Miss Primary Endpoints but Offer Biomarker Insights
ByAinvest
Thursday, Dec 4, 2025 1:12 pm ET1min read
Novo Nordisk presented new topline results from their Evoke and Evoke+ phase 3 trials of semaglutide, an oral GLP-1 drug, at the CTAD conference. The trials did not meet their primary endpoints, but highlighted biomarker findings that offer insight into Alzheimer's pathobiology. The results demonstrated reductions of up to 10% in biomarkers linked to neuroinflammation and Alzheimer's disease. Full results will be presented at the International Conference on Alzheimer's and Parkinson's Diseases in March 2026.
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