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On July 25, 2025, NextCure's stock surged by 23.57% in pre-market trading, driven by the release of promising preclinical data for its novel anti-Siglec-15 antibody, NC605.
NextCure, Inc. has presented encouraging preclinical findings for NC605, demonstrating improved bone microarchitecture and reduced fracture incidence in models of osteogenesis imperfecta. This data was presented at the Brittle Bone Society, highlighting the potential of NC605 as a treatment for brittle bone disease.
The company's recent presentations have focused on the efficacy of NC605 in improving bone health and reducing fractures, which has garnered significant attention from investors. The positive preclinical results have reinforced confidence in NextCure's pipeline and its potential to develop innovative therapies for bone-related conditions.

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