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Moderna Reports Positive Immunogenicity Data for Updated Spikevax Vaccine
ByAinvest
Tuesday, Sep 16, 2025 10:53 am ET1min read
Moderna has reported preliminary immunogenicity data for its updated Spikevax vaccine, showing an 8-fold increase in neutralizing antibodies against the LP.8.1 variant of SARS-CoV-2. The vaccine targets the currently dominant strains in the US and has a consistent safety profile. The update follows reports of Trump administration health officials linking vaccines to 25 child deaths, based on unverified submissions to the Vaccine Adverse Event Reporting System.
Moderna has announced preliminary immunogenicity data for its updated Spikevax vaccine, demonstrating an 8-fold increase in neutralizing antibodies against the LP.8.1 variant of SARS-CoV-2. This variant is currently dominant in the US, and the updated vaccine targets it effectively while maintaining a consistent safety profile [1].The data, which follows recent reports linking vaccines to 25 child deaths based on unverified submissions to the Vaccine Adverse Event Reporting System, underscores the importance of transparency and accurate information in public health initiatives. The Vaccines for Children (VFC) program, supported by the US government, aims to enhance vaccination rates among underserved populations, thereby improving public health outcomes .
The US vaccine market, valued at approximately USD 30 billion, is driven by increasing public health initiatives, rising awareness of vaccine-preventable diseases, and advancements in vaccine technology. Key players such as Pfizer, Moderna, and Johnson & Johnson dominate the market due to their extensive research and development capabilities and established brand recognition [1].
The market is characterized by intense competition, with companies leveraging innovation, regulatory approvals, and strategic partnerships to enhance production and distribution efficiency. Despite challenges such as vaccine hesitancy and supply chain disruptions, the market is poised for substantial growth, driven by technological advancements and increased government support [1].
Moderna's updated Spikevax vaccine represents a significant advancement in the fight against COVID-19, highlighting the potential of mRNA technology in combating emerging infectious diseases. As new variants continue to emerge, the demand for innovative vaccines is expected to rise, particularly in the mRNA and combination vaccine segments [1].
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