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Jake Karls, co-founder of snack bar company Mid-Day Squares, has taken 72 flights this year, mostly for business. To avoid burnout, he optimizes his time by setting up meetings near speaking engagements and packs the same items on every trip, including a mini ab roller, Nike Air Force 1 trainers, and travel-friendly Alo shorts. He prefers red-eye return flights and limits his trips to two days to combat loneliness.

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