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Metagenomi has prioritized its MGX-001 hemophilia A program and laid off 25% of its workforce. The company shared new dose range finding data from the program, demonstrating curative factor VIII activity in non-human primates and informing a clinical dose regimen strategy. Metagenomi plans to advance MGX-001 into clinical development and expects a pre-investigational new drug regulatory meeting in Q4 2025.

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