MediWound's EscharEx Phase II Data Show Strong Link Between Wound Bed Preparation and Closure.

MediWound has published a new study in Advances in Wound Care demonstrating a strong link between wound bed preparation and wound closure in venous leg ulcers. The post hoc analysis of a multicenter randomized controlled trial found a correlation between WBP and wound closure in 119 chronic VLU patients. The study supports wound bed preparation as a critical step in the healing process.

MediWound Ltd. (Nasdaq: MDWD), a global leader in next-generation enzymatic therapeutics for tissue repair, has published a new study in the journal Advances in Wound Care. The study, titled "The Correlation Between Wound Bed Preparation and Wound Closure in Venous Leg Ulcers: A Post Hoc Analysis of the ChronEx Multicenter Randomized Controlled Trial," demonstrates a strong correlation between wound bed preparation (WBP) and wound closure in patients with chronic venous leg ulcers (VLUs) [1].

The post hoc analysis, conducted on data from 119 chronic VLU patients, found that wounds achieving WBP were 4.1 times more likely to close compared to those that did not (p = 0.0004). Notably, wounds failing to achieve WBP had a 90% probability of not healing. Early WBP achievement (within 14 days) showed a significantly increased healing likelihood (Relative Risk = 2.4) [1].

The study validates EscharEx®, MediWound's bromelain-based enzymatic therapy, as a potential accelerator of wound bed preparation and, consequently, improved healing outcomes in venous leg ulcers. EscharEx® has shown clinical advantages over existing enzymatic debridement products and is currently in a global Phase III study for VLUs, with a clinical study in diabetic foot ulcers (DFUs) in preparation [1].

Dr. Marissa J. Carter, a clinical trial specialist and biostatistician focused on chronic wound care research, emphasized the broader implications of the results: "While wound bed preparation has long been accepted as the conceptual foundation for managing chronic wounds, this landmark analysis provides evidence, for the first time, that there is a strong correlation between the two. Importantly, the findings indicate a high negative predictive value associated with the lack of wound bed preparation. In other words, wounds that are not adequately prepared are highly unlikely to proceed to closure, underscoring the essential role of wound bed preparation in the healing process. Without adequate wound bed preparation, chronic wounds rarely heal" [1].

The validation of EscharEx®'s therapeutic approach strengthens its clinical positioning in the chronic wound care market, where effective debridement solutions that can accelerate the preparation phase represent a significant unmet need [1].

References:
[1] MediWound Ltd. (2025). The Correlation Between Wound Bed Preparation and Wound Closure in Venous Leg Ulcers: A Post Hoc Analysis of the ChronEx Multicenter Randomized Controlled Trial. Advances in Wound Care. Retrieved from https://www.stocktitan.net/news/MDWD/medi-wound-announces-new-eschar-ex-phase-ii-data-demonstrating-lis6gh1wiiv1.html