Macro Strength Returns as 2021 ATH Turns Support - Strategic Entry Points in Altcoins and Equity Sectors

The global economy is witnessing a resurgence of macroeconomic strength, with 2021 all-time high (ATH) levels in equities and altcoins reemerging as critical support zones. This shift is driven by a confluence of factors: AI infrastructure expansion, green energy transitions, and sector-specific dislocations in valuation. Investors with a macro lens can capitalize on these dynamics by targeting undervalued altcoins and cyclical equities positioned to benefit from structural tailwinds.

The 2021 ATH as a Macro-Driven Support Level

The 2021 economic rebound, marked by 5.7% U.S. GDP growth and 6.1% global expansion, created a foundation of investor confidence that persists today, according to Festi hf.'s Q3 2025 results. While inflationary pressures and labor market imbalances linger, the 2021 ATH levels in equities (e.g., S&P 500, Nasdaq) have acted as psychological and technical support in 2025, particularly in sectors aligned with AI and green energy, as detailed in the Q3 2025 AI infrastructure report. This is not coincidental: macroeconomic narratives such as AI infrastructure growth and green transition funding are now embedded in asset valuations. For instance, Palantir Technologies (PLTR) surged 300% in 2025, fueled by $10 billion in U.S. Army contracts and $1.5 billion in UK defense AI deals, reflecting Palantir's 300% surge. Such momentum underscores how macro trends can transform historical price levels into dynamic support zones.

Cyclical Equities: Best Buy and Bristol Myers Squibb as Case Studies

Best Buy (BBY) exemplifies a cyclical equity benefiting from macro-driven demand. In Q3 2025, the retailer reported $277 million in earnings, exceeding expectations, and raised full-year guidance, as reported in Best Buy's fiscal Q3 results. Its strategic partnerships, such as with Aluratek to introduce biometric padlocks, position it at the intersection of consumer tech and AI adoption. While the LIBOR transition's direct impact on BBY remains unquantified, its sector momentum-driven by AI-infused retail solutions-suggests resilience against broader macroeconomic headwinds.

Conversely, Bristol Myers Squibb (BMY) highlights the duality of macroeconomic sensitivity. The pharmaceutical giant's Growth Portfolio (Reblozyl, Camzyos) generated $6.9 billion in Q3 2025 revenue, but its Legacy Portfolio declined 12% due to generic competition, according to BMY Q3 2025 earnings. This dichotomy reflects the sector's vulnerability to patent expirations and pricing pressures, yet BMY's GAAP gross margin of 71.9% indicates operational flexibility to navigate these challenges.

Valuation Dislocations in Altcoins: AI and Green Energy Opportunities

While the research lacks direct altcoin examples, macroeconomic drivers such as AI infrastructure and green transition funding create fertile ground for undervalued altcoins. For instance, C3.ai (AI)-though an equity-exhibits altcoin-like volatility, with a 52-week range of $44.35–$183.90, as explained in Why C3.ai Shares Are Falling. Its recent Air Force collaboration and valuation dislocation (forward P/S ratio of 0.8x) suggest it could serve as a proxy for altcoins in AI infrastructure. Similarly, green energy-linked equities like Vertiv (VRTX), which partners with NVIDIA on AI data centers, illustrate the point via Vertiv's NVIDIA partnership.

The Q3 2025 surge in AI infrastructure spending-$650 billion across 150 projects-further validates this thesis, according to the Q3 2025 AI infrastructure report. Altcoins tied to energy-efficient computing or renewable energy projects could mirror the valuation gains seen in Palantir and Vertiv.

Strategic Entry Points and Risk Mitigation

Investors should prioritize assets where macro trends intersect with valuation dislocations:
1. AI Infrastructure Equities/Altcoins: Target companies like C3.ai or altcoins with exposure to AI data centers, leveraging the $165 billion BorderPlex project in New Mexico as a benchmark.
2. Green Energy Transition Plays: Focus on firms or tokens aligned with ESG-driven infrastructure, such as AirTrunk's sustainability-linked loans.
3. Cyclical Equities with Sector Momentum: Best Buy's AI-integrated retail model and BMY's growth portfolio offer asymmetric upside in a macro-strengthening environment.

Conclusion

The return of macro strength, anchored by 2021 ATH levels as support, presents a unique window for investors to capitalize on undervalued assets. By aligning with sectors like AI and green energy-where valuation dislocations and macroeconomic tailwinds converge-strategic entry points can be identified with high conviction. As Palantir's 300% rally and Best Buy's earnings surge demonstrate, the intersection of macro trends and sector-specific momentum is where the most compelling opportunities reside.