Lantheus Shares Tumble 28.58% on $700M Trading Surge to 143rd Rank as FDA Progress and Strategic Moves Unfold

On August 6, 2025, Lantheus Holdings (NASDAQ: LNTH) experienced a 28.58% decline in its stock price despite a 509.23% surge in trading volume to $0.70 billion, ranking 143rd in market activity. The company reported Q2 2025 financial results, including $378.0 million in revenue, $1.12 in GAAP diluted EPS, and $79.1 million in free cash flow. Key developments included FDA acceptance of a new PSMA PET imaging agent formulation with a PDUFA date of March 6, 2026, and the completion of the Life Molecular Imaging acquisition, expanding its portfolio with Neuraceq, a beta-amyloid radiodiagnostic for Alzheimer’s disease. The board authorized a $400 million stock repurchase program, replacing the previous 2024 initiative.

Financial highlights revealed an 8.3% decline in PYLARIFY sales to $250.6 million, contrasting with a 7.5% rise in DEFINITY sales to $83.9 million. Operating income fell 14.4% to $88.0 million, while adjusted operating income dropped 10.8% to $152.6 million. The company revised full-year 2025 guidance, narrowing revenue expectations to $1.475–$1.51 billion from $1.55–$1.585 billion and lowering adjusted EPS guidance to $5.50–$5.70 from $6.60–$6.70. These adjustments reflect integration challenges from recent acquisitions and competitive pressures in the PSMA PET market.

Lantheus also announced the FDA’s expanded label for Neuraceq, enabling its use in identifying candidates for amyloid-targeting therapies. Meanwhile, the pending sale of its SPECT business to SHINE Technologies is expected to conclude by year-end, allowing the company to focus on PET radiodiagnostics and pipeline advancements. The updated corporate strategy emphasizes diversifying revenue streams and enhancing supply resilience through manufacturing upgrades, though near-term performance remains constrained by market dynamics and operational integration costs.

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