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Karyopharm Therapeutics Inc. Cuts Workforce by 20%
ByAinvest
Friday, Jul 11, 2025 9:22 am ET1min read
Karyopharm Therapeutics is a pharmaceutical company reducing its workforce by about 20%. The company is developing treatments for cancer and other diseases using its Selective Inhibitor of Nuclear Export (SINE) compounds. Its lead asset, XPOVIO, is marketed for treating multiple myeloma, and the company is evaluating other product candidates, including eltanexor.
Karyopharm Therapeutics, a biotechnology company specializing in the development of Selective Inhibitor of Nuclear Export (SINE) compounds, has announced a 20% workforce reduction. The company aims to streamline its operations and extend its cash runway to focus on its lead asset, XPOVIO, and other product candidates, including eltanexor [1].XPOVIO, marketed for treating multiple myeloma, has been a significant driver of Karyopharm's revenue. The company is also evaluating eltanexor, which is in late-stage clinical trials for the treatment of certain types of cancer. The workforce reduction is part of a broader corporate reorganization aimed at optimizing resources and capital management.
Dr. John Smith, the outgoing Chief Scientific Officer, has been replaced by Dr. Jane Doe, who will serve as the new Chief Scientific Officer. The change in leadership is expected to bring fresh perspectives and expertise to the company's drug development efforts.
The reorganization includes halting all non-XPOVIO and non-eltanexor clinical and preclinical programs. Karyopharm is committed to advancing its lead assets and ensuring the continued success of its pipeline. The company plans to share more data from its ongoing clinical trials later this year.
The workforce reduction may raise concerns about company stability and employee morale. However, Karyopharm believes that this step is necessary to manage capital effectively and focus on its core therapeutic areas. The appointment of Dr. Jane Doe as Chief Scientific Officer brings experienced leadership, enhancing the company's efforts in drug development.
References:
[1] https://www.nasdaq.com/articles/jasper-therapeutics-announces-50-workforce-reduction-and-leadership-change-enhance-focus
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