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On September 29, 2025,
(INSM) surged 3.37% to close its trading session, with a trading volume of $360 million, marking a 90.11% increase from the previous day. This elevated volume ranked the stock 322nd among all traded equities on the day.The stock's performance was driven by renewed investor confidence in its therapeutic pipeline, particularly the recent FDA acceptance of a supplemental New Drug Application for its anti-fungal treatment. Analysts noted that the regulatory update reinforced the company's strategic positioning in the rare disease sector, though no immediate revenue catalysts were disclosed in the public filings.
Market participants observed that the volume spike coincided with a broader shift in risk appetite, as investors rotated into mid-cap biotech names following macroeconomic data releases. However, the lack of concrete financial guidance from Insmed in recent earnings calls limited the magnitude of the upward move.
In a back-testing scenario, a hypothetical daily-rebalanced portfolio selecting the 500 highest-volume stocks from January 1, 2022, to September 29, 2025, would require a custom execution framework. Current tools support single-instrument analysis or event-based studies but cannot replicate the described strategy without external data inputs, such as pre-defined universe lists or portfolio-level performance metrics.

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