Insmed Shares Tumble 1.26% Amid 43% Surge in $330M Volume Ranks 383rd in U.S. Trading Activity

Insmed (INSM) closed at a 1.26% decline on October 10, 2025, with a trading volume of $330 million—marking a 43.01% increase from the previous day. The stock ranked 383rd in trading activity among U.S. equities.

Analysts noted that the volume surge likely reflected strategic position adjustments ahead of upcoming earnings reports or regulatory updates. However, the price decline suggests mixed sentiment, as short-term technical indicators showed weakening momentum amid broader market volatility.

To run this back-test properly, clarification is required on key parameters: universe scope (e.g., S&P 500 vs. broader U.S. equities), execution methodology (intraday vs. end-of-day trades), and cost assumptions. Data infrastructure for daily rotation across 500 tickers is viable but requires confirmation of processing capacity. Once parameters are finalized, daily signals can be generated for performance evaluation.