Insmed Shares Slide 3.84 as $300 Million Surge Propels Stock to 382nd in US Trading Volume Rankings

On September 25, 2025, Insmed (INSM) closed down 3.84% amid a trading volume of $300 million, representing a 43.04% surge from the previous day’s activity. The stock ranked 382nd in terms of trading volume among U.S.-listed equities, indicating heightened investor engagement despite the price decline.

Recent developments suggest mixed market sentiment. While the increased volume highlights renewed trading interest, the price drop points to potential profit-taking or short-term profit-driven strategies. Analysts note that the stock’s liquidity profile remains robust, with the elevated volume potentially signaling broader institutional or algorithmic activity.

To run a precise back-test I need to pin down a few implementation details that aren’t specified yet: 1. Universe • Do you want the entire U.S. listed equity universe (NYSE + NASDAQ + Amex), or a different market? 2. Ranking & rebalancing rule • “Top 500 by daily trading volume” – should this be re-evaluated every trading day, with the portfolio rebalanced the same day? 3. Entry/exit pricing • Buy at today’s close and sell at tomorrow’s close (close-to-close return), or buy at tomorrow’s open and sell at tomorrow’s close (open-to-close)? 4. Weighting scheme • Equal-weight each of the 500 names, or weight by (for example) dollar volume? 5. Risk controls • Any stop-loss, take-profit, or maximum drawdown constraints, or is it a pure daily rebalance without overlays? Once these points are confirmed I can generate the data retrieval plan, run the back-test, and present the results.