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Ideaya Biosciences has announced clearance for IDE034, a precision medicine oncology company developing targeted therapeutics for patient populations selected using molecular diagnostics. Its lead product candidates include darovasertib (IDE196), IDE397, IDE161, and GSK101. IDE196 is a PKC inhibitor being evaluated as a synthetic lethal combination therapy, while IDE397 is a MAT2A inhibitor for solid tumors with MTAP deletions. IDE161 is a PARG inhibitor for tumors with defined biomarkers based on genetic mutations and/or molecular signatures.

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