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Hewlett Packard Enterprise (HPE) has struck a significant partnership with Lupin Limited, a global pharmaceutical leader, to modernize Lupin’s private cloud infrastructure through HPE’s Private Cloud Enterprise solution. This collaboration underscores a growing trend toward hybrid and private cloud adoption, particularly in regulated industries. For HPE, the deal represents a strategic win in a market where enterprises increasingly prioritize data sovereignty, cost efficiency, and scalability. Let’s dissect the implications for investors.
Lupin, headquartered in Mumbai with operations across 100+ markets, is repatriating workloads from public clouds to HPE’s private cloud platform. The solution integrates edge computing at manufacturing sites with centralized data management, enabling real-time analytics for quality control and production efficiency. HPE’s fully managed service will oversee critical systems like SAP S/4 HANA, reducing Lupin’s IT expenditure while ensuring compliance with stringent pharmaceutical regulations.
This partnership highlights HPE’s ability to address sector-specific needs, from edge computing for manufacturing to data sovereignty for regulated industries. For Lupin, the benefits include faster innovation cycles, reduced carbon footprint, and application-level cost visibility—a trifecta of operational and financial optimization.

The Lupin deal is part of a broader 10% YoY revenue growth in HPE’s Hybrid Cloud segment during Q1 2025, which now accounts for $1.4 billion in quarterly revenue. The partnership also bolsters HPE’s Annualized Revenue Run-Rate (ARR), which surged 46% YoY to $2.1 billion in Q1. This recurring revenue model, underpinned by consumption-based contracts like HPE GreenLake, offers stability in an otherwise volatile tech landscape.
However, HPE’s margins remain under pressure. Server gross margins dropped to 8.1% in Q1 2025—a sharp decline from 11.4% in 2024—due to AI inventory buildup and pricing competition. While the Lupin partnership contributes to services revenue, resolving server margin issues will require strategic cost cuts, such as the announced 5% workforce reduction by 2027.
The U.S. Department of Justice’s antitrust lawsuit against HPE’s $14 billion acquisition of Juniper Networks adds uncertainty. If the merger is blocked, HPE faces a $815 million termination fee and loses opportunities to strengthen its networking portfolio—a critical gap in its cloud services offering. Meanwhile, server margin recovery hinges on transitioning to next-gen AI chips and reducing inventory overhang.
The Lupin partnership exemplifies HPE’s shift toward becoming a hybrid cloud leader, a market projected to grow at a 14% CAGR through 2030. For pharmaceutical giants like Lupin, private clouds are a necessity, not a choice—data sovereignty and regulatory compliance are non-negotiable. HPE’s ability to scale such deals could drive further ARR growth, offsetting server margin headwinds.
Moreover, the partnership aligns with ESG priorities. Lupin’s reduced carbon footprint and cost savings showcase how HPE’s solutions cater to sustainability-driven enterprises—a growing differentiator in tech procurement.
HPE’s collaboration with Lupin is a compelling indicator of its hybrid cloud strategy’s viability. With 10% Hybrid Cloud revenue growth and a 46% ARR expansion, HPE is solidifying its position in a high-growth sector. However, investors must weigh this against near-term risks: margin pressures from server operations and regulatory hurdles with the Juniper deal.
The partnership’s success hinges on HPE’s execution in three areas:
1. Margin Stabilization: Reducing server costs while scaling high-margin cloud services.
2. Juniper Outcome: Securing the merger to bolster networking capabilities.
3. Customer Expansion: Replicating the Lupin model with other regulated industries.
For now, the deal reinforces HPE’s value proposition in a world where enterprises demand cloud agility without compromising control. Investors seeking exposure to hybrid cloud leadership—despite near-term turbulence—may find HPE a compelling long-term play.
Key Data Points:
- HPE’s Hybrid Cloud revenue: $1.4B (+10% YoY) in Q1 2025.
- ARR: $2.1B (+46% YoY).
- Server gross margins: 8.1% (down from 11.4% in Q1 2024).
- Lupin’s global reach: 15 manufacturing sites, 7 R&D centers, 23,000+ employees.
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