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GRI Bio announced positive topline data from its Phase 2a study in idiopathic pulmonary fibrosis (IPF). The study met its primary endpoint, with GRI-0621 being well-tolerated and no severe or serious adverse events. The study also met its secondary endpoints, demonstrating improvement in biomarkers of collagen turnover, suggesting a resolution of fibrosis and repair of the alveolar basement membrane. GRI-0621 showed increases in forced vital capacity (FVC) at 6 and 12 weeks of treatment.
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