Exact Sciences Shares Surge 4.67% to 52-Week High Amid 37.4% Volume Drop Ranks 495th as Technical Breakout Drives Momentum

On September 5, 2025, Exact Sciences (EXAS) rose 4.67% to $53.99, with a trading volume of $220 million, ranking 495th among stocks by turnover, a 37.4% decline from the previous day. The stock touched its 52-week high of $54.355, driven by technical indicators and speculative options activity. Despite sector-wide mixed performance in life sciences tools, EXAS outperformed peers, trading above its 200-day moving average of $51.40 and breaching the upper Bollinger Band at $51.04

Technical analysis highlights overbought conditions, with a Relative Strength Index (RSI) of 77.44 and a MACD histogram of 0.78, signaling strong short-term momentum. Options data shows heightened call buying, particularly in the 54-strike contracts, as traders position for further upside. The stock’s breakout pattern suggests continued bullish pressure, though caution is warranted given RSI proximity to overbought territory. Key resistance remains at $54.355, with support at the 200-day MA

Backtesting of EXAS’s performance reveals a muted short-term impact, with median 1-day excess returns near zero. However, momentum builds gradually, showing a 1.35% average gain by day 10 and a statistically significant 6.4% cumulative outperformance versus benchmarks between days 16–30. Win rates improve with holding periods, peaking at ~65% around days 13–18. The current surge aligns with historical patterns where extended holding periods yield stronger returns

Exact Sciences’ recent rally is a high-conviction technical breakout, but sustainability depends on maintaining above key levels. Aggressive bulls may target the EXAS20250912C54 contract for a potential break above $54.355. Investors are advised to monitor the 54.355 level for confirmation and the 51.18 intraday low for reversal signals