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Ethereum's open interest has declined to 11.59 million ETH, the lowest level since May 2025, as traders on the Chicago Mercantile Exchange (CME) overtook Binance to become the largest
derivatives market [1]. The CME's dominance reflects growing institutional demand, with U.S. spot Ethereum ETFs holding 6.79 million ETH, or 5.7% of the circulating supply [1]. Meanwhile, Ethereum's price has fallen to $4,105, struggling to hold the $4,100 support level after a rejection at $4,270 [1].The decline in open interest follows a "leverage flush" last Friday, with total open interest dropping to 11.04 million ETH before a modest recovery. Historically, such drawdowns in leverage often coincide with cautious market sentiment and short-term price consolidation [1]. Profit realization has spiked, with investors booking over $800 million in gains in the past 24 hours, while whale activity remains steady, with holdings increasing by over 110,000 ETH [1].

Technical analysis indicates Ethereum faces critical resistance at $4,270. A break above this level could target $4,500, but failure to hold the $4,100 support might push prices toward $3,470. The Relative Strength Index (RSI) and Moving Average Convergence Divergence (MACD) suggest bearish momentum, with the RSI failing to confirm bullish dominance after a recent rejection at $4,270 [1].
The CME's growing influence is underscored by its role in facilitating Ethereum exposure through regulated futures and ETFs. This shift aligns with broader institutional adoption, as Ethereum ETFs have attracted $547 million in inflows, signaling confidence in the asset class [1]. However, market participants remain cautious, with liquidations totaling $240.9 million in the past 24 hours, including $150 million in long positions [1].
Analysts note that the CME's dominance, combined with ETF accumulation, could reshape Ethereum's market dynamics. While the current price action reflects short-term volatility, long-term fundamentals-such as Ethereum's role as a settlement layer for Layer-2 networks-remain intact [1].
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