Eisai and Biogen Present New Data on LEQEMBI's Effectiveness in Reducing Neurotoxic Aβ Protofibrils in CSF.

Tuesday, Dec 2, 2025 4:41 pm ET1min read

Eisai and Biogen presented data at the CTAD Conference 2025, confirming the pharmacological effect of LEQEMBI (lecanemab-irmb) on Aβ protofibrils in CSF. The study demonstrated that lecanemab binds to PF, mitigating their toxic effects and slowing Alzheimer's disease progression. The data showed a statistically significant increase in total CSF PF concentration with lecanemab treatment compared to placebo, and a correlation between PF changes and neurodegeneration biomarkers was observed in the placebo group but not with lecanemab treatment.

Eisai and Biogen Present New Data on LEQEMBI's Effectiveness in Reducing Neurotoxic Aβ Protofibrils in CSF.

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