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Eisai and Biogen presented data at the CTAD Conference 2025, confirming the pharmacological effect of LEQEMBI (lecanemab-irmb) on Aβ protofibrils in CSF. The study demonstrated that lecanemab binds to PF, mitigating their toxic effects and slowing Alzheimer's disease progression. The data showed a statistically significant increase in total CSF PF concentration with lecanemab treatment compared to placebo, and a correlation between PF changes and neurodegeneration biomarkers was observed in the placebo group but not with lecanemab treatment.

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