Day One 2025 Q2 Earnings Deepened Losses Despite Record Revenue Surge

Day One reported Q2 2025 earnings on August 6, 2025, with revenue surpassing expectations but a sharply widened net loss. The company did not adjust full-year guidance, maintaining its 2025 net product revenue forecast of $140–$150 million.

Revenue
Day One’s total revenue soared by 313.9% year-over-year to $33.91 million, driven primarily by robust product sales. Specifically, product revenue, net, reached $33.56 million, while license revenue contributed $346,000, collectively driving the record performance.

Earnings/Net Income
The company’s losses expanded significantly, with a net loss of $30.32 million in Q2 2025, a 588% increase from $4.41 million in Q2 2024. On a per-share basis, the loss widened to $0.29 from $0.05, reflecting a 480% increase in losses. Despite the deepening loss, the company noted that this marked the highest net income in the past 12 months.

Price Action
The stock of Day One recorded a 0.94% decline on the latest trading day, with a 1.57% drop during the previous week, but gained 1.18% month-to-date.

Post-Earnings Price Action Review
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CEO Commentary
Jeremy Bender, Ph.D., CEO of Day One, highlighted the company’s strong operational performance and momentum as it moves into the second half of the year. He emphasized the continued focus on growing OJEMDA revenue, advancing the clinical pipeline, and expanding the portfolio with financial discipline, reinforcing a commitment to value creation for patients and shareholders.

Guidance
The company reaffirmed its 2025 full-year net product revenue guidance of $140 to $150 million. It also expects to release 3-year follow-up data from the FIREFLY-1 clinical trial in Q4 2025 and anticipates completion of patient enrollment in the pivotal Phase 3 FIREFLY-2 trial by mid-2026.

Additional News
Recent news from DAWN highlighted a range of cultural, legal, and social developments across Pakistan. A new strain of Foot-and-Mouth Disease has triggered a crisis among Punjab’s cattle farmers, with alarming mortality rates reported. Meanwhile, the U-16 men’s volleyball team’s recent championship win signaled a growing presence for the sport in the region. In the arts sector, Karachi hosted an exhibition showcasing a deeply personal collection of work that blends humor, beauty, and resilience. On the legal front, the suspension of the Committee for the Welfare of Prisoners has raised concerns over access to justice for Sindh’s most vulnerable. Additionally, women have been at the forefront of a rising tourism revolution in Pakistan, establishing safe and inclusive spaces for travel and wellness retreats.