Bruker Spatial Biology Unveils Revolutionary Advances at AGBT 2025

Bruker Spatial Biology, a division of Bruker Corporation (Nasdaq: BRKR), is set to unveil groundbreaking advancements in spatial biology at the 2025 Advances in Genome Biology and Technology (AGBT) General Meeting. These innovations, which include the CosMx Whole Transcriptome Panel (WTX), expanded GeoMx protein panel, PaintScape platform, and enhanced CellScape PowerOMX software engine, are poised to revolutionize the field of spatial biology and drive significant market growth.

1. CosMx Whole Transcriptome Panel (WTX): The CosMx WTX assay enables the detection and quantification of over 18,000 RNA transcripts at single-cell and subcellular resolution. This breakthrough technology preserves spatial single-cell resolution while offering genomic breadth comparable to traditional single-cell RNA sequencing. The WTX assay is designed to be used on the CosMx Spatial Molecular Imager (SMI) platform, which can analyze multiple samples simultaneously, ensuring high throughput and efficiency. Orders for the CosMx Human Whole Transcriptome Panel will commence in April, with commercial shipments expected this summer. A Mouse version is expected to launch later in 2025.

2. Expanded GeoMx Protein Panel: Bruker is expanding its GeoMx protein panel to spatially profile 1000 proteins in addition to the entire transcriptome. This evolution of GeoMx into a powerful multiomic platform enables simultaneous, same-section, multiomic analysis of the whole transcriptome and 1000 proteins. The 1K Panel on the GeoMx is expected to ship this summer, further differentiating the meaning of multiomic and driving market growth.

3. PaintScape Platform: Bruker's new PaintScape platform opens a new frontier in the field of spatial biology. Leveraging unique jebFISH™ technology, PaintScape enables researchers to perform multiplexed, direct visualization of genome architecture and chromosomal structure in individual single cells with ultra-high spatial resolution. By providing a detailed view of the 3D genome, PaintScape empowers researchers to understand how genome structural variations impact gene expression and their implication in the mechanisms of disease.

4. Enhanced CellScape PowerOMX Software Engine: Bruker is enhancing its CellScape platform for spatial proteomics with the new PowerOMX™ Engine. This software engine, which powers the CellScape's EpicIF technology, seamlessly feeds data to the recently launched CellScape Navigator GUI. PowerOMX includes streamlined data processing and optimized performance, ensuring that researchers can build assays by combining panels and/or individual markers, even after the conclusion of an experimental run. This enhancement further solidifies the CellScape platform's position as the most flexible high-throughput spatial biology imaging solution available.

The simultaneous announcement of these four major spatial biology innovations signals Bruker's aggressive push to dominate the rapidly growing spatial biology market, estimated to reach $2.1 billion by 2025. These technological breakthroughs are strategically significant, as they address critical market needs for comprehensive spatial transcriptomics, high plex protein profiling, 3D genome visualization, and enhanced spatial proteomics performance. By offering a suite of cutting-edge spatial biology instruments, assays, software, data analytics, and CRO services, Bruker Spatial Biology is well-positioned to capture a larger share of the spatial biology market and drive revenue growth in its life sciences segment.

In conclusion, Bruker Spatial Biology's upcoming announcements at AGBT 2025 represent a significant leap forward in the field of spatial biology. With the CosMx Whole Transcriptome Panel, expanded GeoMx protein panel, PaintScape platform, and enhanced CellScape PowerOMX software engine, Bruker is set to revolutionize the market and drive innovation in spatial biology research and applications.