Bristol-Myers Squibb’s Q1 Earnings Signal Strategic Shift to Growth—But Challenges Linger

Bristol-Myers Squibb (NYSE: BMY) delivered a robust first-quarter 2025 earnings report, with total revenue of $11.2 billion exceeding analyst expectations of $10.7 billion. The results underscore a critical transition toward growth-driven therapies amid declining legacy products, but the path forward remains fraught with risks tied to generic competition and clinical setbacks. Let’s dissect the numbers and their implications for investors.

Key Financial Highlights

On a GAAP basis, BMS reported net income of $2.5 billion ($1.20 per share), a dramatic rebound from a net loss of $11.9 billion ($5.89 per share) in Q1 2024. The prior-year loss was amplified by a $12.9 billion non-cash charge from the 2024 Karuna acquisition and SystImmune collaboration. Excluding one-time items, non-GAAP earnings rose to $1.80 per share, up from a loss of $(4.40) a year earlier.

Ask Aime: "Understanding Bristol-Myers Squibb's earnings growth and market impact"

Total revenue fell 6% year-over-year, but this decline masks a stark division in performance:
- Growth Portfolio: Generated $5.6 billion, a 16% increase (18% excluding foreign exchange), driven by Opdivo ($2.3B in combined sales), Breyanzi (146% growth), Camzyos (89% growth), and the U.S. launch of Cobenfy.
- Legacy Portfolio: Declined 20% to $5.6 billion, pressured by generics eating into Revlimid and Pomalyst, alongside Medicare Part D reforms.

Ask Aime: "Will BMS's growth portfolio offset declining legacy products with Oxyfend's market debut?".

Cost Discipline Fuels Profitability

The turnaround was fueled by aggressive cost-cutting:
- SG&A expenses dropped 33% to $1.6 billion, reflecting strategic productivity initiatives and the absence of prior-year acquisition costs.
- R&D spending fell 16% to $2.3 billion, with ongoing efficiencies.

Growth vs. Legacy: A Dual-Track Strategy

BMS’s focus on its Growth Portfolio—including oncology, immunology, and rare diseases—is paying off. The 16% revenue growth in this segment contrasts sharply with the 20% decline in legacy products. Management emphasized that the shift is intentional, with resources redirected toward high-margin therapies like Camzyos (hypertrophic cardiomyopathy) and Breyanzi (CAR-T cell therapy).

However, legacy drugs still account for nearly half of revenue. The loss of exclusivity on Revlimid, a $5 billion+ product, continues to weigh on results. Investors must assess whether the Growth Portfolio can offset this erosion long-term.

Pipeline Progress and Pitfalls

BMS’s pipeline delivered mixed news:
- Opdivo/Yervoy combos won FDA approvals for first-line hepatocellular carcinoma and microsatellite instability-high colorectal cancer, expanding their oncology dominance.
- Breyanzi secured European approval for follicular lymphoma, while Sotyktu showed strong safety and efficacy in psoriatic arthritis trials.

Yet, two major setbacks cloud optimism:
1. Cobenfy’s Phase 3 trial for schizophrenia missed its primary endpoint, dashing hopes for a new antipsychotic.
2. Camzyos’s ODYSSEY-HCM trial failed to meet dual endpoints for non-obstructive hypertrophic cardiomyopathy, complicating its market potential.

These failures highlight the high-risk nature of drug development, even for top-tier firms.

Updated Guidance: A Vote of Confidence

BMS raised its 2025 revenue guidance to $45.8–$46.8 billion (from $45.5B) and non-GAAP EPS to $6.70–$7.00 (up $0.15 midpoint). The upgrades reflect confidence in the Growth Portfolio’s momentum and $500 million of favorable foreign exchange impacts. Management also noted $100 million in higher other income, driven by royalties and interest.

Risks on the Horizon

• Generic Competition: Revlimid’s decline could accelerate as generics gain traction.
• Regulatory and Trial Uncertainties: Cobenfy’s failure and Camzyos’s mixed results may require costly retooling of trials or marketing strategies.
• Economic and Political Factors: The guidance excludes potential tariff impacts or new acquisitions/divestitures, which could introduce volatility.

Conclusion: A Glass Half-Full, But Cracks Remain

BMS’s Q1 results are a testament to its ability to pivot toward growth, with cost discipline and strategic divestments shielding profitability. The 16% growth in the Growth Portfolio and $500 million FX tailwind suggest BMS can meet its upgraded guidance. However, the 20% decline in legacy revenue and pipeline stumbles remind investors that this is far from a sure bet.

The stock’s performance will hinge on whether the Growth Portfolio can sustain momentum without major setbacks. With $46 billion in cash and a streamlined portfolio, BMS is positioned to weather near-term headwinds. Yet, investors should demand clear evidence of late-stage pipeline wins—particularly in Camzyos’s remaining indications—to justify current valuations.

In short, BMS is navigating a risky but necessary transition. For now, the earnings report buys management time—but the next phase of clinical trials and commercial execution will be critical.