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On September 25, 2025,
(BSX) closed with a 0.08% increase, marking a modest gain despite a 33.76% decline in trading volume to $920 million, placing it 109th in market liquidity among listed stocks. The subdued trading activity contrasts with recent volatility in the medical device sector, where earnings reports and regulatory updates typically drive price movements.Market participants are scrutinizing the firm’s positioning amid broader sector trends. While no immediate catalysts were reported, analysts highlight that Boston Scientific’s performance often correlates with macroeconomic indicators and healthcare policy shifts. Investors are advised to monitor upcoming guidance from the FDA or Medicare reimbursement adjustments, which historically influence valuations in the space.
To build a daily-rebalanced “top-500-by-volume” portfolio for back-testing, several parameters require clarification: 1. **Universe**: Define the exchange or index scope (e.g., U.S. equities, NYSE/NASDAQ) for selecting the 500 stocks. 2. **Trade timing**: Confirm execution conventions—standard practice involves buying at the next day’s open and selling at the same day’s close for one-day holding periods. 3. **Weighting method**: Equal-weighting (0.2% per stock) is standard but alternatives may be considered. 4. **Practical constraints**: The current back-testing engine supports single-ticker studies. For multi-asset portfolios, options include creating a synthetic index of the 500 stocks or using an ETF proxy like SPY as a benchmark.
A detailed data plan will be outlined once these preferences are confirmed, enabling the back-test to run from January 3, 2022, through the current date. This approach ensures reproducibility and alignment with market conditions during the specified period.

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