BeOne Medicines Institutional Ownership: A Closer Look

BeOne Medicines Ltd. (NASDAQ:ONC) has a high institutional ownership of 42%. The top 6 shareholders own 52% of the company. Insiders have been selling shares lately.

BeOne Medicines Ltd. (NASDAQ: ONC), formerly known as BeiGene, has seen a significant increase in institutional ownership, with the top six shareholders now holding 52% of the company. This comes on the heels of a strong second quarter 2025 earnings report, which highlighted robust growth and positive free cash flow expectations.

According to recent 13F filings, institutional investors now hold 42% of BeOne's shares, up from previous levels. Major investors such as BlackRock, Geode Capital Management, State Street, and Vanguard have increased their positions in BeOne, reflecting the company's inclusion in the Russell 2000 index. While these acquisitions are primarily index-driven and mechanical, they represent a meaningful acknowledgment of BeOne's fintech and digital asset platform development [1].

In addition to the strong institutional presence, BeOne's lead product, BRUKINSA, continues to perform well. Global sales for BRUKINSA surged by 49% year-over-year (YoY) in the second quarter 2025, reaching $950 million. This growth is driven by the drug's efficacy in liquid cancers like CLL and MCL, as well as its leading share in new patient starts in the BTK inhibitor class in the U.S. [2].

However, insiders have been selling shares lately, which may indicate a cautious outlook among some key stakeholders. This selling activity could be due to various factors, including legal battles, market conditions, or strategic decisions. BeOne is currently involved in legal disputes with AbbVie over patent infringement and trade secret misappropriation, but recent developments have weakened AbbVie's infringement claims [2].

BeOne's balance sheet remains strong, with $2.756 billion in total cash and cash equivalents as of its last report. The company also generated $571.2 million in cash from operations in the trailing twelve months. The recent sale of IMDELLTRA royalty rights to Royalty Pharma plc (RPRX) for up to $950 million will further bolster BeOne's financial position [2].

Overall, BeOne Medicines Ltd. is well-positioned with a strong institutional ownership base and robust financial performance. However, investors should remain vigilant regarding ongoing legal disputes and insider selling activities.

References:
[1] https://www.stocktitan.net/news/MFH/mercurity-fintech-expands-institutional-ownership-with-black-rock-72znqkgayuai.html
[2] https://seekingalpha.com/article/4816713-beone-medicines-brukinsa-leadership-royalty-sale-signal-stronger-future