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AstraZeneca's (AZN.US) potential blockbuster ADC receives breakthrough therapy designation

Market IntelTuesday, Dec 10, 2024 1:20 am ET

1min read

AstraZeneca (AZN.US) and Daiichi Sankyo announced that the U.S. FDA granted breakthrough therapy designation to datopotamab deruxtecan (Dato-DXd), a Trop2-targeting antibody-drug conjugate (ADC), for the treatment of adult patients with non-small cell lung cancer (NSCLC) who have EGFR mutations and whose disease has progressed after EGFR tyrosine kinase inhibitors (TKIs) and platinum-based chemotherapy. This is the first breakthrough therapy designation for datopotamab deruxtecan, according to the press release.

The FDA granted the breakthrough therapy designation mainly based on the data from the TROPION-Lung05 clinical 2nd phase trial, and supported by the data from the TROPION-Lung01 clinical 3rd phase trial. The partial results of TROPION-Lung05 trial, which were presented at the American Society of Clinical Oncology (ASCO) annual meeting this year, showed that the intracranial (IC) objective response rate (ORR) was 22% (95% CI: 6–48) in 18 patients with target brain lesions who had previously treated locally advanced or metastatic NSCLC. Among the 18 patients, 10 (56%) had a total reduction in the size of brain tumors.

Comments

Straight_Turnip7056

05/16

ALTBG is like a gambler in a Bitcoin casino, betting big on a volatile market. Their stock's rollercoaster ride shows the risks of relying on Bitcoin's price swings. With all that debt and potential dilution, they're rolling the dice. If Bitcoin hits, they win big; if not, they might be left with a losing hand. It's a high-stakes game, and only time will tell if they've got the winning hand or a bust.

istockusername

05/16

@Straight_Turnip7056 Yikes, that's a lot of debt.

Connect_Corner_5266

05/16

@Straight_Turnip7056 True, it's a high-risk play.

TheosophOracle

05/16

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12 hour ago

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CrisCathPod

05/15

Gotta diversify beyond GBM, NWBO. More pipelines!

Relevations

05/15

Betting on immunotherapy is always dicey. Roll the dice.

Artistic_Studio2784

05/15

NWBO is the ultimate Hail Mary pass. Only throw if you've got nothing to lose and everything to gain.

maximalsimplicity

05/15

Sawston facility is the unsung hero here. GMP compliance is the difference between boom and bust.

SeriousTsuki

05/15

NWBO's pipeline is like a lottery ticket. Buy with caution and a long breath. 🚀

Arturs727

05/15

Burn rate vs. timeline is the tightrope walk. One misstep and it's curtains. Who's got the patience?

Hamlerhead

05/15

NWBO's pipeline beyond GBM is like finding gold in a mine. Solid tumors could mean solid gains.

Certain-Dragonfly-22

05/15

$NWBO might need a lifeline soon. Watch funding moves.

jvdr999

05/15

DCVax-L's data looks solid, but regulatory hurdles are the Great Wall of China. Who's ready for the marathon?

Doxfinity

05/15

DCVax-L could moon if approved. Eyes on UK.

Overlord1317

05/15

Combo therapies might be the secret sauce. Keep an eye on those trials for hidden gems.

Harpnut

05/15

Risky play here, but potential's huge. Long-term hold.

Really_Schruted_It

05/15

Risky business, but if NWBO hits, we're talking life-changing. Not for the faint-hearted!

Silgro94

05/15

Gotta love the biotech rollercoaster. NWBO's ride is particularly bumpy but potentially moon-worthy.

ServentOfReason

05/15

Market cap is a steal if DCVax-L delivers. Betting on NWBO is like backing a dark horse race winner.

Gnurx

05/15

@ServentOfReason What's your target entry point?

Thanhansi-thankamato

05/15

@ServentOfReason Totally agree, NWBO's undervalued.

StovetopAtol4

15 hour ago

"Talk about a budget bill on a collision course with an iceberg! Johnson’s 'Titanic' of a bill is set to sail through the House, but will it survive the Senate’s ice floes? With deadlines looming and lawmakers bickering like Jack and Rose over a lifeboat, this fiscal adventure might just go down in history—literally. Let’s hope they don’t need a 'Rosebud' moment when it all sinks.

jabnabbar

15 hour ago

@StovetopAtol4 If this budget bill is the Titanic, then the Senate must be the iceberg. But hey, maybe they'll pull an Elon and make it a Mars budget—lots of room for fiscal growth, but a long way to go before splashdown.

highrollerr90

16 hour ago

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15 hour ago

@highrollerr90 How long were you holding TSLA, and what's your plan with the gains?

wangaa

19 min ago

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59 min ago

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2 hour ago

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04/22

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2 hour ago

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FreeIcecreamAfterDin

51 min ago

@wangaa K boss

StephCurryInTheHouse

04/24

Uniper's Q1 hit hard, but long-term vision still intact. Renewables are the future, but they need to fix supply chain mess.

GarlicBreadDatabase

04/24

EU asset sales could free up capital. Silver lining?

NRG1788

04/24

Holding $UNPR for long term, eyes on renewables.

qw1ns

04/24

Diversify or die trying—Uniper's pivot to renewables is smart, but EU asset sales could hurt. Risky road ahead.

coinfanking

04/24

$UNPR might be a value play post-Q1 fallout. High risk, high reward. Not adding to my portfolio yet.

Crazy-Ad-7869

04/24

@coinfanking How long you planning to hold $UNPR if you decide to buy?

foureyedgrrl

04/24

Uniper's hedging strategy looks shaky, folks. 🤔

GME_Butt_Stallion

04/24

@foureyedgrrl Hedging's tough when prices drop.

SnowySalesman

04/24

Diversify beyond Russian gas, Uniper. Risky business

deepvalueresearch

04/24

@SnowySalesman True, Uniper's Russia gamble risky.

Dynasty__93

04/24

Uniper's Q1 loss feels like a speed bump on a highway to renewables. Long-term vision or time to bail?

styletrick

04/24

@Dynasty__93 What's your take on Uniper's long-term potential?

vivifcgb

04/24

Market already priced in the pain. Investors skeptical but not bearish. Waiting for Uniper's next move. 🤔

HJForsythe

04/24

Geopolitical risks are a major overhang. 🤷♂️

vannucker

04/24

Lower commodity prices hit margins hard. Ouch!

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04/24

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04/24

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04/18

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02/16

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02/16

$UBER 150 Dec 25

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02/16

@SuperRedHulk1 How long you planning to hold $UBER at 150? Any specific target in mind?

magenta_placenta

02/16

@SuperRedHulk1 I had $UBER once, sold too early. Regretted it when it kept rising. FOMO hits hard.

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02/16

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02/16

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02/16

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Stevitop

02/16

$GOOGL seeing a lot of call options this week

psycho_psymantics

02/16

Elon's always been about pushing boundaries, but this UK crackdown might make him rethink his playbook. 🤔

Hoshigetsu

02/16

Fees could spike, gotta watch those tech stocks.

ttforum

02/16

Uber throwing shade on fees—might be time for them to renegotiate or rethink their UK strategy.

PancakeBreakfest

02/16

UK trying to be the safest online? Sounds good, but regulatory headaches could choke innovation.

InjuryIll2998

02/16

Tech firms threatening to leave over fees and regs? Sounds like classic negotiation tactics. They might get a deal sweetened.

destroyman26

02/16

Ofcom's role is crucial, but the phased approach feels like a recipe for confusion.

scccc-

02/16

@destroyman26 True, the phased approach might cause confusion. Ofcom needs to be clear with their timeline and guidelines.

Ironman650

02/16

@destroyman26 yep, could be messy

ethereal3xp

02/16

Google worried about service quality? Maybe the UK needs to dial back the regulations a notch.

mrkitanakahn

02/16

@ethereal3xp True, UK regs might be too tight.

Virtual_Information3

02/16

@ethereal3xp Maybe chill on the rules, UK?

investortrade

02/16

Tech exodus would be a shame, UK needs that talent pool. Maybe revisit the fees and regulations?

1kczulrahyebb

02/16

@investortrade Revisit fees? Maybe. Balance is key.

S_H_R_O_O_M_S999

02/16

Elon's drama king vibes, but UK regs tightening.

rltrdc

02/16

@S_H_R_O_O_M_S999 Drama king alert, but who's holding the popcorn? 🚀

Holiday_Context5033

02/16

Google worried about stifling UK growth? Maybe they should hedge their bets and diversify instead of depending on one market.

11thestate

02/16

@Holiday_Context5033 Diversify? Easy for them to say.

Anklebreakers10

05/10

Coeur Mining's EBITDA jump is wild. 28% QoQ? That's some serious operational FLEX. Wonder how they'll maintain that momentum in Q2.

ArgyleTheChauffeur

05/10

Silver lining for $CDE, anyone? 📈🔥 SilverCrest acquisition was a game-changer. Long-term hold for me, watching those CAS targets closely.

Airmang74

05/10

$CDE's free cash flow turn from -$14.4M to $17.6M is insane. Liquidity boost from bullion sales was the secret sauce here.

PlatHobbits7

05/10

Silver lining for $CDE, anyone? 🤔

mrdebro44

05/10

Coeur's EBITDA jump is wild, stonks only go up?

Sweet-Block5118

05/10

Las Chispas acquisition = game changer, no cap

JRshoe1997

05/10

Gold and silver pumping, who's hodling? 📈

highrollerr90

05/10

@JRshoe1997 I'm hodling too, got a small stack in silver ETFs. It's been a solid ride so far.

featherbirdcalls

05/10

@JRshoe1997 How long you planning to hodl? Got any specific targets in mind?

Revolutionary-Slip48

05/10

Silver lining for $CDE, anyone? 🤔

W0mb0comb0

05/10

@Revolutionary-Slip48 Bullish vibes or just a flash in the pan? 📈🤔

cyarui

05/10

Las Chispas is a gem. High-grade discoveries and low costs? Coeur's making savvy moves in the silver sector. 🌟

HTPGibson

05/10

@cyarui Las Chispas ain't no joke, but Coeur's debt reduction is the real MVP.

Character_Economy928

05/10

@cyarui Low costs, sweet. But watch out for volatility in silver prices.

sithtimesacharm

05/10

Wow!the block option data in CDE stock saved me much money!

BB-LETS-GO

05/10

@sithtimesacharm How long you been holding CDE? What's your avg buy-in?

sniper459

04/22

Rapid diagnostics game changer, sepsis survival depends on speed.

vivifcgb

04/22

Rapid diagnostics game changer. Sepsis doesn't wait, and neither should we. Time is blood, right?

ExeusV

04/22

LIAISON PLEX® system's targeted approach means less over-testing, less waste. Hospitals love cost-effective, smart diagnostics.

SomeSortOfBrit

04/22

Gram-negative panel's specificity is a breath of fresh air. Less contamination, less headache. 🙌

iamsam22222

04/22

NanoGrid tech rocks, fewer false positives, more trust.

SmallVegetable4365

04/22

FDA clearance for Diasorin's Gram-Negative panel is a game-changer. Rapid diagnostics can significantly reduce sepsis mortality. 🚑💡

goldeneye700

04/22

Holding $DSN long-term, precision diagnostics is future 💰

VegetaIsSuperior

04/22

@goldeneye700 How long you holding $DSN? You think it's a multi-bagger?

Silgro94

04/22

$DSN's LIAISON PLEX® is a must-have for ICUs.

Luka77GOATic

04/22

Gram-negative panel + Gram stain = targeted therapy win

THEPR0P0TAT0

04/22

Wow!the Peak Seeker algorithm successfully identified both trough and apex inflection points in DNA equity's price action, while my execution latency resulted in material opportunity cost.

Mr_Biddz

04/22

@THEPR0P0TAT0 Sure

IsItSetToWumbo

05/17

Wow!The CDE stock was in a clear trend, and I made $294 from it!

joleshole

05/13

OMG!I successfully capitalized on the NVDA stock's bearish trend, generating $240!

usernambe

05/13

@joleshole How long were you holding NVDA before selling?

Sweet-Block5118

04/22

$BA Not many are talking about the Airbus A330 engine fire Imagine if it was a Boeing jet

owter12

04/21

A $8–$9B deal with a 4.5% interest rate is a sweet loan for bidders. Citigroup and Apollo are making it easy for Thoma Bravo to play.

skarupp

04/21

@owter12 Sweet deal, huh? Citigroup and Apollo are really bending over backwards for Thoma Bravo.

Urselff

04/21

This deal feels like a turning point. Aerospace industry focusing more on digital infrastructure is a trend we'll likely see more of.

Monkiyness

04/21

Risky business with regulatory hurdles, but Thoma Bravo has experience navigating these WATers. They're not new to a challenge.

aiolyfe

04/21

Thoma Bravo's move? Pure genius. Capitalizing on digital aviation is the way to go. 🚀

whatclimatecrisis

04/22

@aiolyfe What do you think about Boeing's strategy?

Interesting_Mix_3535

04/21

Private equity firms eyeing Jeppesen like vultures on a carcass. Can't blame them, though. Lucrative opportunity

getintocollegern

04/21

Jeppesen's EBITDA looks solid. 26.7x–30x multiple ain't cheap, but it's a premium for a critical asset. Private equity firms see the potential.

CurlyDarkrai

04/22

@getintocollegern True, PE firms eye growth.

Puzzleheadbrisket

04/21

Boeing's struggles make this sale a smart play. Focusing on core business and reducing debt is the way to go. Long-term, they might be weaker in integrated solutions, but it's a trade-off.

AGailJones

04/22

@Puzzleheadbrisket True, Boeing's debt's a weight.

Surfin_Birb_09

04/21

Boeing's move smart; debt down, focus on core.

car12703

04/22

@Surfin_Birb_09 Smart move, but debt's still heavy.

user74729582

04/22

@Surfin_Birb_09 Boeing's call: debt down, focus tight.

mrpoopfartman

04/21

Jeppesen's digital future looks bright with Thoma Bravo.

Anonym0us_amongus

04/21

@mrpoopfartman Agreed, Thoma Bravo's a solid play.

Rtic92

04/22

@mrpoopfartman What's next for Jeppesen?

lookingforfinaltix

04/21

Private equity firms eyeing aviation's sweet spot.

mav101000

04/21

@lookingforfinaltix What's next for aviation?

chrisbaseball7

04/21

I'm holding $AAPL and a bit of $TSLA, but considering adding aviation stocks. This sector feels like it's gearing up for change.

QuantumQuicksilver

04/21

Boeing offloading Jeppesen makes sense. Focus on core biz and ditch the baggage. Smart play

birdflustocks

04/21

Thoma Bravo's move could mean big things for aviation tech. They're not just buying a company, they're future-proofing their portfolio.

LonnieJaw748

04/21

Boeing's debt is a beast. Cutting $7B with this sale is smart. They can focus on flying machines instead of navigation systems.

LarryKingsGhost

05/09

Analysts bullish on $CDE. Cantor Fitzgerald gives thumbs-up. Time to load up or nah?

pellosanto

05/09

SilverCrest acquisition looks like a jackpot. Silver bugs rejoice. $CDE ready to shine.

RadioactiveCobalt

05/09

Coeur's ESG game strong, SRI funds probably biting. Good vibes for long-term holders. 🚀

F-uPayMe

05/10

@RadioactiveCobalt Coeur's ESG is solid, SRI funds might be in.

SnowySalesman

05/09

Coeur's ESG focus might be a game-changer; SRI investors could keep driving the premium valuation.

Anonym0us_amongus

05/09

Coeur's ESG game strong, SRI investors happy

joaopedrosp

05/09

Debt-to-equity at 0.18? Coeur's got financial FLEX. Mining stocks don't get better than this

RamBamBooey

05/09

SilverCrest acquisition = game changer for $CDE.

DumbStocker

05/09

Gold and silver to the moon! 🤑

AP9384629344432

05/09

Holding $CDE long-term, solid growth potential here.

BarrettGraham

05/09

Damn!!The CDE stock generated the signal, from which I have benefited significantly!

missmypinto

7 min ago

Damn!!the Peak Seeker algorithm successfully identified both trough and apex inflection points in TSLA equity's price action, while my execution latency resulted in material opportunity cost.

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