Applied Therapeutics shares surge 11.89% premarket on FDA meeting update and leadership changes boosting rare disease prospects.

think> Okay, let's tackle this query step by step. The user provided a stock performance for Applied Therapeutics (APLT) with a premarket increase of 11.89% and a list of recent news events. The goal is to determine if the stock's movement is due to any of the news events and summarize it in a Bloomberg-style paragraph. First, I need to check the stock movement: it's up 11.89% in premarket. Rounded to two decimals, that's 11.89%. The trading period is premarket. Next, evaluate the news events. The recent events include: 1. A Yahoo Finance headline that's not detailed, just mentions "BC-Most Active Stocks" from AP. This might not be relevant. 2. A Simply Wall St. article from 3 days ago asking if changes in leadership and FDA dialogue can reshape APLT's path in rare diseases. The stock is up 30.19% here, but the user's current movement is 11.89%. The timing is 3 days ago, which is before the premarket move. However, the article's question might indicate positive sentiment if there's progress. 3. GlobeNewswire on Q3 2025 financial results from 4 days ago. Again, the stock is up 30.19% in the news, but the timing is older. The user's movement is in premarket, so this might not be the immediate cause. 4. Another Simply Wall St. article from a month ago about a 19% drop and institutional steps. The stock is up 30.19% here, but this is older and bearish, which doesn't align with the current upswing. 5. GlobeNewswire about an FDA meeting update from a month ago. The stock is up 30.19% here. Again, timing is a month ago, so not directly linked to the premarket move. 6. Other financial results and leadership appointments from 3-9 months ago. The stock is up 30.19% in those news items, but again, the timing is older. The most recent news is the Yahoo Finance one, but it's vague. The Simply Wall St. article from 3 days ago mentions changes in leadership and FDA dialogue. If the stock has been up in the news before, but the current premarket move is also up, maybe the recent FDA dialogue is the key. However, the FDA meeting was a month ago. Wait, there's another news item from 17 hours ago: "BC-Most Active Stocks" from Associated Press. That's the most recent. But the summary is just "Something went wrong," so maybe not useful. Wait, the first news event listed is "Reason 1: title: Applied Therapeutics, Inc. (APLT) Latest Stock News & ... summary: Applied Therapeutics, Inc. (APLT) Latest Stock News & Headlines - Yahoo Finance. Something went wrong. Skip to main content. News. content: BC-Most Active Stocks Associated Press Finance • 17h ago APLT +30.19% AMIX KXIN..." So the 17h ago news is from Associated Press, mentions APLT up 30.19% as part of "Most Active Stocks." But the content is just that; it's not a specific event. Maybe it's just highlighting the stock's activity, not a new event causing the move. So the recent news doesn't include a specific event from the last 17 hours that would cause the premarket move. The other news is older. The user's instruction says to evaluate each news event's relevance. The most recent one is the Associated Press one, but it's not a cause, just a report on activity. The other news is from 3 days ago (leadership and FDA dialogue), but the stock's movement is in premarket, which might be after that news. Wait, the user's stock movement is in premarket now. If the news from 3 days ago was positive, could that be the reason? But the stock's movement is a 11.89% increase, which is a big jump. However, the news from 3 days ago mentions the possibility of changes in leadership and FDA dialogue reshaping the path, but it's a question, not a confirmed event. Alternatively, maybe the stock's movement is due to a new development not listed in the provided news. But the user's instruction says to use the given news. Since the most recent news is the Associated Press one from 17h ago, but it's not a cause, and the other news is older, maybe there's no relevant news. Wait, the user's input has a lot of news entries, but all of them are either older or don't specify a new event. The problem is.